Data and figures are provided on the effects of fluoxetine, a selective serotin reuptake inhibitor (SSRI) antidepressant, on the gut microbiome and metabolome in a rat model to better understand the effect of this drug on women during gestation and lactation. Throughout pregnancy and lactation, female rats received the SSRI fluoxetine or vehicle. High resolution 16S ribosomal RNA marker gene sequencing and targeted metabolic analysis were used to assess the fecal microbiome and metabolic availability, respectively.
The UMM Biorepository is a resource building effort that includes banking of blood samples from UMMS patients as well as collections of various biospecimens from collaborating UM researchers. State-of-the-art robotic freezer and liquidhandling equipment offer a secure and managed environment for biospecimen processing, storage and distribution. Data connected to the samples is obtained through the electronic health record and/or study-specific data collection, allowing for multi-disciplinary research that can impact a range of health issues. Access to data and biospecimens is dependent upon specific study requirements.
The National Health and Nutrition Examination Survey (NHANES) is a program of studies designed to assess the health and nutritional status of adults and children in the United States. Participants are selected via a random sampling method. The survey is unique in that it combines interviews and physical examinations. The NHANES interview includes demographic, socioeconomic, dietary, and health-related questions. The examination component consists of medical, dental, and physiological measurements, as well as laboratory tests administered by highly trained medical personnel.
The Health Outcomes and Measures of the Environment (HOME) Study, a prospective pregnancy and birth cohort in the greater Cincinnati OH metropolitan area, was established to determine whether early life environmental chemical exposures influence children’s health. Data include longitudinal and repeated measures of chemical exposures and child health beginning in the gestational age of 16.0 weeks with follow ups until 8 years of age. This includes 100+ environmental chemical exposures measured in women and children, as well as repeated measures of child neurodevelopment, anthropometry, respiratory and allergy outcomes, and injuries.