UMB Dataset
Refinement of a Live Attenuated Salmonella enterica Serovat Newport Vaccine with Improved Safety
UID: 207
- Description
- Non-typhoidal Salmonella (NTS) is responsible for approximately 93 million cases of gastroenteritis annually. Little research has been directed towards a development of vaccines against Salmonella serogroups O:6,7 or O:8. Researchers constructed a live attenuated serogroup O:8 vaccine, CVS 1979, by deleting guaBA, htrA, and aroA from the genome of S. Newport. Over the course of 6 weeks, 6 to 8-week-old female BALB/c mice were immunized with live attenuated S. Newport vaccine CVD 1979 or sterile phosphate buffered saline (PBS) three times. Four weeks after the last immunization, mice were challenged intraperitoneally (i.p.) with wild-type Salmonella strains to assess the homologous and heterologous protection elicited by the live attenuated S. Newport vaccine CVD 1979.
Access
- Restrictions
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Unrestricted access
- Instructions
- The data presented in this study are contained within the article and supplementary material.
Interventional
- Grant Support
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U19 AI109776-01/National Institute of Allergy and Infectious Diseases (U.S.)5T32DK067872-15/National Institute of Health (U.S.)