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  • A 2-Year Clinical Evaluation of Fissure Sealants
    UMB Dataset

    Alternate Title(s)
    Evaluation of Resin Based and Glass Ionomer Based Sealants Placed With or Without Tooth Preparation
    Authors
    Vineet Dhar
    Haiyan Chen
    Description

    25 children ranging in age from 6 to 10 years participated in this bilateral split-mouth study evaluating two dental sealants for retention and secondary caries development. Data were collected comparing resin based and glass ionomer based sealants with and without tooth preparation at 6-month intervals over a 2 year period. Dataset includes demographic and clinical measures and sealant performance evaluation and comparison at 6, 12, 18 and 24 months.

    Subject
    Dental Materials
    Geographic Coverage
    India
    Timeframe
    2007 - 2009
    Access Rights
    Application Required
  • Amish Complex Genetic Disease Database
    UMB Dataset

    Description

    The Amish Research Group of the University of Maryland School of Medicine has been studying the Old Order Amish population in Lancaster County, PA, since 1993. This database currently consists of health-related data on over 7,000 adults resulting from studies ranging from population and basic science to clinical and translational research. Areas of investigation include: Cardiovascular Risk, Diabetes, Bone Health, Blood Pressure, Vascular Imaging, Aging, Breast Tissue Density, Platelet Aggregation, Microbiome, Wellness, and Brain Imaging. Extensive genetic data (genotyping and sequencing) is also available.

    Subject
    Amish
    Ethnic Groups/Genetics
    Genetics, Population
    Health Status Indicators
    Geographic Coverage
    Pennsylvania
    Timeframe
    1995 - Present
    Access Rights
    Access granted on an individual basis dependent upon request and consent considerations
    Local Experts
    Alan R. Shuldiner
    Braxton C. Mitchell
  • Caregiver Treatment Preferences for Children with Attention Deficit/Hyperactivity Disorder
    UMB Dataset

    Alternate Title(s)
    Caregiver Treatment Preferences for Children with ADHD
    Authors
    Susan dosReis
    Description

    This dataset is the result of an investigation of caregivers’ management and treatment preferences for their ADHD child. From January 2013 through March 2015 a total of 184 caregivers of children 4 to 14 years of age were recruited from primary care, pediatric outpatient clinics, and support organizations in Maryland. The study explored caregiver variability and priorities when considering medication, change in management options over time, and preference for different treatment attributes. Data were collected using Best-Worst scaling and the Vanderbilt ADHD Diagnostic Parent Rating Scale (VADPRS). This dataset consists of caregiver and child demographic information, child diagnoses and treatment characteristics data, and caregiver preferences with regard to medication and observed and desired improvements in their child’s ADHD.

    Subject
    Attention Deficit Disorder with Hyperactivity
    Caregivers
    Geographic Coverage
    Maryland
    Timeframe
    2013 - 2015
  • Clinical Study Reports (CSR) Used in the Systematic Review of Neuraminidase Inhibitors for Preventing and Treating Influenza in Healthy Adults and Children with Confirmed or Suspected Exposure to Natural Influenza
    UMB Dataset

    Alternate Title(s)
    CSRs used in Cochrane review of neuroaminidase inhibitors for influenza
    Authors
    Peter Doshi
    Description

    Dataset consists of 107 full clinical study reports (CSRs) of published and unpublished randomized, placebo-controlled clinical trials of two neuraminidase inhibitors. A systematic review of the CSRs and other regulatory documents was conducted to determine the potential benefits and harms of oseltamivir (Tamiflu) and zanamivir (Relenza). Outcome measures included time to first alleviation of symptoms, influenza outcomes, complications, admissions to hospital, and adverse events in the intention to treat population. Completeness of relevant parts of the CSRs was determined via an extraction form based on the CONSORT statement checklist. Authors have provided the full set of clinical study reports for both medications provided to the Cochrane collaboration by Roche, GlaxoSmithKline, and the European Medicines Agency (EMA) for use in the systematic review of these neuraminidase inhibitors for treating/preventing influenza in healthy adults and children. A guest post on the "Dryad News and Views" site regarding the dataset of clinical study reports and the resulting Cochrane systematic review is available at: https://blog.datadryad.org/2014/04/17/tamiflu-data/

    Subject
    Influenza, Human
    Access Rights
    Free to All
  • Comparison of In Vivo Expression Levels of IL-4 and IL-4d2 in Mouse Lung Tissue
    UMB Dataset

    Alternate Title(s)
    Comparison of In Vivo Expression Levels of IL-4 and IL-4 delta2 in Mouse Lung Tissue
    Authors
    Sergei P. Atamas
    Description

    The primary goal of this project was to compare in vivo gene expression levels of the cytokine, IL-4, and its natural splice variant, IL-4δ2, in the lungs of mice. Intratracheal replication-deficient adenovirus-mediated gene delivery of mouse IL-4 or IL-4δ2 was utilized to create three mice overexpressing IL-4 and three overexpressing IL-4δ2 in their lungs. An additional three mice were similarly infected with control AdV-NULL virus not encoding a cytokine. 14 days postinfection, lung tissue was homogenized, total RNA extracted, and results analyzed. The data demonstrate that IL-4 and its splice variant differentially affect global gene expression which has implications for the use of targeted therapy for various diseases. The dataset consists of 9 microarray data tables corresponding to each of the samples. Additionally, a supplementary TAR file of the raw data is also available to download.

    Subject
    Gene Expression Profiling
    Microarray Analysis
    Timeframe
    2010 - 2010
    Access Rights
    Free to All
  • Comparison of Mortality and Hospital Utilization Patterns Between Older Order Amish and Non-Amish Caucasians
    UMB Dataset

    Authors
    Braxton C. Mitchell
    Description

    This dataset consists of comparisons of mortality and hospital discharge rates/diagnoses between Old Order Amish (OOA) living in Lancaster County, Pennsylvania, and non-Amish Caucasians. The Anabaptist Genealogy Database Version 5 (AGDB5) and the Framingham Heart Study (FHS) were utilized for the mortality statistics for each cohort, respectively. Additionally, OOA health-related data were collected from hospital discharge records from 4 Lancaster County hospitals while the National Hospital Discharge Survey (NHDS) was used for non-Amish Caucasians. For each discharge the principal diagnosis and up to 6 additional diagnoses were recorded using ICD-9-CM codes. The dataset consists of demographics, mortality statistics, hospital discharge and diagnoses data, as well as longevity and health-related comparison analyses between the two groups.

    Subject
    Amish
    Hospitals/Utilization
    Longevity
    Geographic Coverage
    Pennsylvania
    Timeframe
    2002 - 2004
  • Dataset (data extraction spreadsheet) of an Exploratory Review of Clinical Study Reports of Randomised Controlled Trials
    UMB Dataset

    Authors
    Peter Doshi
    Tom Jefferson
    Description

    This dataset (data extraction spreadsheet) is associated with an exploratory evaluation of pharmaceutical industry clinical study reports (CSR) for possible use in evidence synthesis and systematic reviews. 78 CSRs from public sources were selected for data extraction. The report dates range from 1991 through 2011, inclusive, and represent 90 randomized controlled trials of 14 pharmaceuticals. The primary outcome measures include presence and length of essential elements of trial design and reporting and compression factor (ratio of page length for CSRs compared to its published counterpart in a scientific journal). The dataset is comprised of an audited table of extracted and derived variables the details for which are described in an accompanying readme file. The uncorrected (original) and corrected extraction sheets as well as audit records are available upon request from Peter Doshi, corresponding author (pdoshi@rx.umaryland.edu).

    Subject
    Drug Industry
    Access Rights
    Free to All
  • Enhancing Recovery in Coronary Heart Disease Patients

    Alternate Title(s)
    ENRICHD
    Description

    This dataset is the result of a randomized clinical trial to determine the effect of cognitive therapy and selective use of SSRIs on the morbidity and mortality of depressed myocardial infarction patients. Recruitment of participants took place between October 1996 and October 1999 with the trial terminating in 2001. Data were collected for 2481 study participants, 1243 of whom received usual care and 1238 underwent intervention treatment. The dataset includes demographic information, medical characteristics and history, physical examination, current medications, clinical values, and treatment data and outcomes. A total of 38 different files may be combined based on type of data needed.

    Subject
    Myocardial Infarction/psychology
    Geographic Coverage
    United States
    Timeframe
    1996 - 1999
    Access Rights
    Submission of a request via link on the BioLINCC site
    Local Experts
    Erika Friedmann
  • Factors Associated with Outcomes of Pre-ART HIV Care
    UMB Dataset

    Alternate Title(s)
    Factors Associated with Outcomes of Pre-Antiretroviral HIV Care
    Authors
    Kristen A. Stafford
    Lucy W. Nganga
    Tuhuma Tulli
    Karen G. Fleischman Foreit
    Description

    In 2015 the World Health Organization (WHO) eliminated CD4 restrictions for initiating antiretroviral therapy (ART) for people living with HIV (PLHIV) in developing countries. However, the success of therapy is also dependent upon additional health and demographic characteristics of HIV patients at the time they enroll in care. This study investigated pre-ART (time between enrollment and initiation of ART) factors associated with transition to therapy. Data was compiled from a review of 195,011 records of ART-naïve adults enrolled in HIV care and treatment facilities supported by AIDSRelief in Kenya and Tanzania. The outcome variable was transition out of pre-ART care by one of 4 mutually exclusive modes: started ART, died before ART initiation, lost to follow-up (LTFU), and transferred to another facility. The following baseline covariates were analyzed for their relevance to the mode of transition: sex, age at enrollment, CD4 count at enrollment, presence of tuberculosis at enrollment, presence of cryptococcal disease at enrollment, presence of other active opportunistic infections, and year of enrollment in care. The dataset includes demographic data and clinical measures.

    Subject
    HIV Infections
    Geographic Coverage
    Kenya
    Tanzania
    Timeframe
    2004 - 2011
  • Foster Parent Focus Groups for Improving Engagement in the Court Process
    UMB Dataset

    Authors
    Corey S. Shdaimah
    Description

    This dataset is the result of 6 focus groups of Maryland foster parents and their experiences with the court process. The groups were recruited from Baltimore City (2), Baltimore County (1), Montgomery County (1), Queen Anne’s County (1), and Allegany County (1) with a total of 45 participants. The guided discussions concentrated on the factors that either hindered or promoted foster parent involvement in the court process as well as suggestions for improvement. The dataset consists of verbatim transcripts of the group dialogs incorporating issues such as communication, accurate information, and the court environment/setting.

    Subject
    Foster Home Care
    Geographic Coverage
    Maryland
    Timeframe
    2015 - 2015
    Access Rights
    Author approval required