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Results Found: 88
  • A 2-Year Clinical Evaluation of Fissure Sealants
    UMB Dataset

    Alternate Title(s)
    Evaluation of Resin Based and Glass Ionomer Based Sealants Placed With or Without Tooth Preparation
    Authors
    Vineet Dhar
    Haiyan Chen
    Description

    25 children ranging in age from 6 to 10 years participated in this bilateral split-mouth study evaluating two dental sealants for retention and secondary caries development. Data were collected comparing resin based and glass ionomer based sealants with and without tooth preparation at 6-month intervals over a 2 year period. Dataset includes demographic and clinical measures and sealant performance evaluation and comparison at 6, 12, 18 and 24 months.

    Subject
    Dental Materials
    Geographic Coverage
    India
    Access Rights
    Application Required
  • Amish Complex Genetic Disease Database
    UMB Dataset

    Description

    The Amish Research Group of the University of Maryland School of Medicine has been studying the Old Order Amish population in Lancaster County, PA, since 1993. This database currently consists of health-related data on over 7,000 adults resulting from studies ranging from population and basic science to clinical and translational research. Areas of investigation include: Cardiovascular Risk, Diabetes, Bone Health, Blood Pressure, Vascular Imaging, Aging, Breast Tissue Density, Platelet Aggregation, Microbiome, Wellness, and Brain Imaging. Extensive genetic data (genotyping and sequencing) is also available.

    Subject
    Amish
    Ethnic Groups/genetics
    Genetics, Population
    Health Status Indicators
    Geographic Coverage
    Pennsylvania
    Access Rights
    Access granted on an individual basis dependent upon request and consent considerations
    Local Experts
    Alan R. Shuldiner
    Braxton C. Mitchell
  • Analysis of Rickettsia typhi-Infected and Uninfected Cat Flea (Ctenocephalides felis) Midgut cDNA Libraries: Deciphering Molecular Pathways Involved in Host Response to R. typhi Infection
    UMB Dataset

    Authors
    Abu F. Azad
    Sheila M. Dreher-Lesnick
    Shane M. Ceraul
    Sky C. Lesnick
    4 more author(s)...
    Description

    Murine typhus is a febrile disease caused by the bacterium, Rickettsia typhi (R. typhi), and transmitted via infected fleas. This study investigated midgut responses of infected versus uninfected cat fleas (Ctenocephalides felis) by constructing cDNA libraries and examining transcript levels. Select C. felis serine proteases, GTPases and defense response genes were compared to identify differences in gene expression between the two states of infection. A total of 1152 transcripts from both libraries were sequenced, generating 906 high quality sequences, 472 from the uninfected and 434 from the infected midgut library.

    Subject
    Ctenocephalides
    Gene Expression Profiling
    Rickettsia typhi
    Transcription, Genetic
    Timeframe
    2009
    Access Rights
    Free to All
  • Antipsychotic Treatment Among Youth in Foster Care
    UMB Dataset

    Authors
    Susan dosReis
    Yesel Yoon
    David M. Rubin
    Mark A. Riddle
    2 more author(s)...
    Description

    Data from Medicaid fee-for-service and managed care claims from one Mid-Atlantic state were analyzed for this cross-sectional study. The dataset consists of a total of 16,969 youths under the age of 20 with a mental health diagnosis and a pharmacy claim for antipsychotic medication in 2003. Data for each individual includes demographic, Medicaid program category (ie, foster care, disabled), psychiatric diagnostic codes, and psychotropic medications by major therapeutic class.

    Subject
    Child, Foster
    Medicaid
    Psychotropic Drugs
    Timeframe
    2003
  • Assessment of the Real-World Safety Profile of Vedolizumab Using the United States Food and Drug Administration Adverse Event Reporting System
    UMB Dataset

    Authors
    Raymond K. Cross
    Michael Chiorean
    Francis Vekeman
    Yongling Xiao
    3 more author(s)...
    Description

    For two decades the standard drug therapy for patients with Crohn’s disease (CD) and ulcerative colitis (UC) has been anti-tumor necrosis factor agents (anti-TNFs) such as adalimumab (Humira), certolizumab pegol (Cimzia), infliximab (Remicade) and several others. More recently, vedolizumab (Entyvio) has entered the market as the first gut-selective integrin blocker that offers an alternative treatment for inflammatory bowel disease (IBD). Using the FDA Adverse Event Reporting System (FAERS) database, this study compared adverse event reports (AE) for the two types of therapies. The search retrieved 499 reports for vedolizumab and 119,620 for anti-TNFs for the years 1998 through 2015. Using the proportional reporting ratio (PPR) and the empirical Bayesian geometric mean (EBGM) algorithms, AE data were reviewed for signals of disproportionate reporting for the two types of drugs. This dataset includes statistical summary tables of characteristics (demographic) and a variety of adverse event comparisons of vedolizumab, anti-TNFs, and all other medications. Cleaned FAERS data was provided with permission by DrugLogic, Inc. Interested researchers may contact DrugLogic Inc. (Reston, VA) by calling 800-393-1313 or emailing swordham@druglogic.com

    Subject
    Colitis, Ulcerative/drug therapy
    Crohn Disease/drug therapy
    Drug-Related Side Effects and Adverse Reactions
    Access Rights
    Access to cleaned, mapped, de-duplicated and normalized raw FAERS data requires permission of DrugLogic, Inc.
  • Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM)

    Alternate Title(s)
    AFFIRM
    Description

    The AFFIRM clinical trial was instituted to compare the impact on total mortality between two treatment strategies for managing atrial fibrillation (AF): maintenance of sinus rhythm (includes control of heart rate) and control of heart rate alone. Anticoagulation was used with both treatments. 4060 patients from over 200 sites in the U.S. and Canada participated in the study. All enrollees had AF and at least one additional risk factor for stroke or death. Dataset includes patient baseline characteristics, clinical measures, medications, hospitalizations, major adverse events and mortality, and cognitive ability assessments as well as selected quality of life measures.

    Subject
    Arrhythmias, Cardiac
    Geographic Coverage
    Canada
    United States
    Access Rights
    Submission of a request via link on the BioLINCC site
    Local Experts
    Erika Friedmann
  • Attitudes About Stimulant Medication for Attention-Deficit/Hyperactivity Disorder Among African American Families in an Inner City
    UMB Dataset

    Authors
    Susan dosReis
    Arlene Butz
    Paul H. Lipkin
    Julia S. Anixt
    2 more author(s)...
    Description

    This dataset consists of survey responses from 57 African American parents/caregivers whose child was receiving care for ADHD in a university-affiliated pediatric primary care unit. The 47 item questionnaire entitled Attitudes, Satisfaction, Knowledge, and Medication Experiences (ASK-ME) was developed by the primary author to assess views of stimulant medication for ADHD. In addition to demographic information, the dataset includes treatment characteristics, whether or not the child received counseling, and responses to 7 items specifically related to attitude toward medication. A copy of the survey is available from Dr. Susan dosReis upon request.

    Subject
    Attention Deficit Disorder with Hyperactivity
    Caregivers
    Psychotropic Drugs
    Geographic Coverage
    Baltimore (Md.)
  • Attribute Development Using Continuous Stakeholder Engagemement to Prioritize Treatment Decisions: A Framework for Patient-Centered Research
    UMB Dataset

    Authors
    Susan dosReis
    Wendy Castillo Camelo
    Melissa M. Ross
    Marcy Fitz-Randolph
    2 more author(s)...
    Description

    This study investigated a systematic process for using qualitative data to identify attributes and levels most important to caregivers in making health care treatment decisions. Grounded theory methodology was selected for its suitability in assessing an individual’s response to a specific experience. Stakeholder advisors worked with academic researchers in all phases of the project. A total of 48 caregivers were recruited from community support groups from across Maryland. Criteria for selection were a) responsibility for a child 26 years or younger, b) who had an intellectual, emotional, or social developmental disability and, c) with a concomitant mental health condition. 6 caregivers participated in in–depth interviews while the remaining 42 were distributed among 6 focus groups. This dataset includes family demographics, child characteristics (e.g. school grade level, diagnoses, treatment, behavioral problems, etc.), interview transcripts, focus group data, and attribute descriptions and levels.

    Subject
    Caregivers
    Comorbidity
    Decision Making
    Developmental Disabilities
    Geographic Coverage
    Maryland
  • Availability of Study Protocols for Randomized Trials Published in High-Impact Medical Journals: A Cross-Sectional Analysis
    UMB Dataset

    Authors
    Peter Doshi
    O'Mareen Spence
    Kyungwan Hong
    Richie Onwuchekwa Uba
    Description

    To improve reporting transparency and research integrity, some journals have begun publishing study protocols and statistical analysis plans alongside trial publications. To determine the overall availability and characteristics of protocols and statistical analysis plans this study reviewed all randomized clinical trials (RCT) published in 2016 in the following 5 general medicine journals: Annals of Internal Medicine, BMJ, JAMA, Lancet, and NEJM. Characteristics of RCTs were extracted from the publication and clinical trial registry. A detailed assessment of protocols and statistical analysis plans was conducted in a 20% random sample of trials. Dataset contains extraction sheets (as SAS data files), code to calculate the values in the tables in the manuscript, and a supplemental file with additional notes on methods used in the study.

    Subject
    Randomized Controlled Trials as Topic
    Access Rights
    Free to All
  • Best-Worst Scaling to Prioritize Outcomes Meaningful to Caregivers of Youth with Mental Health Multimorbidities: A Pilot Study
    UMB Dataset

    Authors
    Susan dosReis
    Wendy Castillo Camelo
    Melissa M. Ross
    Saad Tariq
    Description

    This pilot study tested the use of a best-worst scaling (BWS) instrument to aid caregivers of a child with mental health comorbidities in clarifying preferences for treatment outcomes. BWS methodology closely approximates real-life decision-making by requiring the selection of one “most important” and one “least important” among a group of competing attributes. 38 caregivers were recruited from support groups in Maryland from March through July of 2015. Criteria for participation were a) their child was 21 years or younger, b) was diagnosed with a developmental delay related to cognitive or emotional disability and, c) with a comorbid mental illness (i.e. ADHD, depression, anxiety, etc.). Subsequent to survey completion, the caregivers took part in one of 6 debriefing sessions to determine the ease of comprehension, relevance of the concepts, distinctiveness of the statements, and clarity of language. The dataset includes family demographics, child characteristics (diagnoses, type of treatment, etc.), session transcripts, and statistics associated with the caregiver responses to the attributes included in the BWS instrument.

    Subject
    Caregivers
    Comorbidity
    Decision Making
    Developmental Disabilities
    Geographic Coverage
    Maryland
    Timeframe
    2015

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