Description: Data and figures are provided on the effects of fluoxetine, a selective serotin reuptake inhibitor (SSRI) antidepressant, on the gut microbiome and metabolome in a rat model to better understand the effect of this drug on women during gestation and lactation. Throughout pregnancy and lactation, female rats received the SSRI fluoxetine or vehicle. High resolution 16S ribosomal RNA marker gene sequencing and targeted metabolic analysis were used to assess the fecal microbiome and metabolic availability, respectively.
Geographic Coverage: Groningen (Netherlands)

Subject of Study

Subject Domain

Keywords

Restrictions: Unrestricted access
Instructions: The sequencing dataset supporting the conclusions of this article is freely available in the European Nucleotide Archive. Other downloadable data is within the article.; Access via European Nucleotide Archive (ENA)

Accession #: PRJEB30296 (ERP112729)

Associated Publications

Data Type

Software Used

Kyoto Encyclopedia of Genes and Genomes (KEGG)

Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt)

Random Forests implemented in R version 3.4.1

Study Type

Empirical Research

Dataset Format(s)

FTP, Galaxy

Data Collection Instruments

PSP® Spin Stool DNA Kit

MiSeq

mothur v. 1.39

QIIME version 1.9.1

ChimeraSlayer

Ribosomal Database Project (RDP) classifier v 2.2

PyNAST

FastTree

Shannon Diversity Index

UniFrac

Grant Support: 660152-DEPREG/European Union’s Horizon 2020 research and innovation program

25206/NARSAD young investigator grant

Fulbright/Fulbright Center The Netherlands

P50-MH099910, MH 104184, MH 091258, MH 087597, MH 073030, and MH 108286/National Institutes of Mental Health

MH 109298/National Institutes of Health National Research Service Award F32
Other Resources: Supplementary Material
accessible from the article via zip file

Antidepressant treatment with fluoxetine during pregnancy and lactation modulates the gut microbiome and metabolome in a rat model relevant to depression