UMB Dataset
IFNa induces CCR5 in CD4+ T cells of HIV patients causing pathogenic elevation
UID: 226
- Description
- This study analyzed samples from 73 healthy donors and 81 individuals with HIV, divided into Natural Viral Suppressors (NVS), untreated non-EC patients (UP), and treated patients (TP). Samples were collected from various sources and subjected to serological, phenotypic, and virological assessments. Peripheral blood mononuclear cells (PBMCs) were isolated, CD4+T cells were stimulated, and flow cytometry was used to measure CCR5 and CXCR4 expression. Viral stocks were prepared from infectious molecular clones (IMCs), and virus growth kinetics were assessed. Immunophenotypic studies, cytokine quantification, and gene expression analyses were conducted.
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Unrestricted access
- Instructions
- Source data for the main figures in the manuscript can be accessed at figshare.
Observational
- Grant Support