UMB Data Catalog
A project of the Health Sciences and Human Services LibraryApproaches to Potentiated Neuroprotective Treatment in the Rodent Model of Ischemic Optic Neuropathy
UMB Dataset
UID: 206
- Description
- Nonarthritic anterior ischemic optic neuropathy (NAION) commonly causes sudden optic nerve (ON)-related vision loss. The rodent NAION model (rAION) closely resembles NAION in presentation and physiological responses. Researchers hypothesized that blocking pro-inflammatory prostaglandin (PGE2) production by inhibiting monoacylglycerol lipase or cyclooxygenase activity and co-administering PGJ2 would potentiate RGC survival following ischemic neuropathy. This study identified early rAION-associated optic nerve head (ONH) inflammatory gene expression responses and the anti-inflammatory prostaglandin PGJ2’s effects on those responses. Deep sequencing was performed on vehicle- and PGJ2-treated ONHs 3d post-rAION induction. Results were compared against responses from a retinal ischemia model. Animals were treated with PGJ2 and MAGL inhibitor KML29, or PGJ2 + COX inhibitor meloxicam. RGC survival was quantified by stereology.
- Timeframe
- 2021
-
Access via Figshare
Datatables
Access via ArticleDatatables, images
- Access Restrictions
-
Unrestricted access
- Access Instructions
- Data available via article and Figshare
- Associated Publications
- Data Type
- Equipment Used
-
planoconver contact lensrat fundus contact lenswarming pads
- Software Used
-
Stereo Investigator 10
- Study Type
-
Interventional
- Dataset Format(s)
- Microsoft Excel
- Dataset Size
- 3.8MB
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