This study generated a replicable neighborhood-level physical activity location availability score (PALAS) from data variables associated with physical activity among adolescents. This score was used to determine if a relationship exists between PA and PA location availability in Baltimore City, Maryland. Nine PALAS component variables were applied to 218 locations. Private PA location variables were created in 2014 through a double-blind research procedure using pre-identified search terms in Google Maps. All other variables were obtained, compiled, and modified from existing digital spatial data layers, spanning 2010-2013 from the Capital Improvement office inventories at the Baltimore City Department of Recreation and Parks. 555 adolescent girls were recruited from 22 Baltimore city public schools serving predominantly low-income communities to participate in a health promotion study between 2009 and 2012. Height was measured using a portable stadiometer and weight was measured using the TANITA TBF-300 body composition scale. Gender-specific BMI-for-age percentiles were generated using CDC 2000 growth indices. An Actical accelerometer was used to track activity for at least 7 consecutive days. Home addresses were geocoded using ArcGIS software by ESRI.

Using the framework of the historical analysis presented to the Senate Subcommittee on Antitrust and Monopoly, drug prices relative to income in the United States are compared to other Organization for Economic Co-Operation and Development (OECD) countries to improve treatment access and affordability. Countries were selected based on drug price and income data availability and inclusion in the OECD. 40 drugs, 20 brand name and 20 generic, were selected based on revenue sales and prescription volume in 2018. Domestic pricing data included list price, measured by Average Wholesale Price (AWP), and retail price available on GoodRx.com. International drug price data was sourced from publicly available databases on individual country websites. The first analysis illustrates the percentage of household disposable income needed to cover a year supply of a select product. The second analysis illustrates country-specific difference in drug affordability. The last analysis examines the percent of resources an average family, about three persons, would spend on medication in the United Sates if they were a member of different income groups.

Through a systematic review, this study collected published and unpublished data on human parainfluenza virus (hPIV) burden to estimate the global and regional number of hPIV-associated acute lower respiratory infections (ALRI) cases, hospitalizations, and mortality by children under five years (stratified 0–5 months, 6–11 months, and 12–59 months) for 2018. The datasets include incidence rates of hPIV-associated ALRI, hospitalization rates of hPIV-associated ALRI, hospitalization rates of hPIV with hypoxemia, in-hospital case fatality ratios of hPIV-associated ALRI, and proportion positives of hPIV in hospitalized ALRI. The data was collected to help guide health investment priorities and resource allocation to accelerate the development of targeted prevention and treatment interventions.

This dataset is associated with a pilot study investigating the relationship of alcohol consumption to the motives and affective states among residents in a continuing care retirement community. Data were collected from 71 volunteer participants in 3 phases over a 9 day period: an initial face-to-face interview, daily telephone surveys, and a final telephone interview on the last day of the study. The dataset includes sociodemographic variables, physical and mental health measures (including depressive symptoms), daily alcohol consumption statistics utilizing the NIAAA standard drink graphic, and drinking motives assessment data.

Nonarthritic anterior ischemic optic neuropathy (NAION) commonly causes sudden optic nerve (ON)-related vision loss. The rodent NAION model (rAION) closely resembles NAION in presentation and physiological responses. Researchers hypothesized that blocking pro-inflammatory prostaglandin (PGE2) production by inhibiting monoacylglycerol lipase or cyclooxygenase activity and co-administering PGJ2 would potentiate RGC survival following ischemic neuropathy. This study identified early rAION-associated optic nerve head (ONH) inflammatory gene expression responses and the anti-inflammatory prostaglandin PGJ2’s effects on those responses. Deep sequencing was performed on vehicle- and PGJ2-treated ONHs 3d post-rAION induction. Results were compared against responses from a retinal ischemia model. Animals were treated with PGJ2 and MAGL inhibitor KML29, or PGJ2 + COX inhibitor meloxicam. RGC survival was quantified by stereology.

This dataset was generated to investigate long-lasting neurobiological adaptations to drugs of abuse. This dataset specifically supported the study of cocaine exposure impact of mitochondrial dynamics and morphology through early growth response factor 3 (Egr3) transcriptional regulation of mitochondria-related nuclear gene transcripts. Mitochondria-related nuclear genes were assayed following contingent or non-contingent cocaine exposure in rodents and were also examined in postmortem nucleus accumbens (NAc) of cocaine dependents.

Supplemental data in tabular forms include human demographics, DNA sequencing primers, mitochondrial statistical analysis, and gene regulations.

The following data elements were observed over a period of 7-10 days: Egr3 change in response to cocaine vs saline between rats and human postmortem issue; Egr3 binding changes in various genes promoting mitochondria in response to cocaine vs saline between rats and human postmortem issue; mRNA change in response to cocaine and saline between rats and human postmortem issue and between cocaine addict and control group; mRNA change in response to cocaine and saline between rats and human dead issue; Ribosome (the RNA binding proteins) associated mRNA changes in dopamine receptor-1 containing medium spiny neurons (D1 MSNs) and D2 MSNs in response to cocaine and saline between cocaine addict and control group.