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- Antibodies, Neutralizing/immunology 1
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UMB Dataset
Antidepressant treatment with fluoxetine during pregnancy and lactation modulates the gut microbiome and metabolome in a rat model relevant to depression
- Authors
- Anouschka S. RamsteijnEldin JašarevićDanielle J. HouwingTracy L. Bale1 more author(s)...
- Description
Data and figures are provided on the effects of fluoxetine, a selective serotin reuptake inhibitor (SSRI) antidepressant, on the gut microbiome and metabolome in a rat model to better understand the effect of this drug on women during gestation and lactation. Throughout pregnancy and lactation, female rats received the SSRI fluoxetine or vehicle. High resolution 16S ribosomal RNA marker gene sequencing...
- Subject
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Antidepressive AgentsLactationPregnancy
- Access Rights
- Unrestricted access
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UMB Dataset
Deep dissection of the antiviral immune profile of patients with COVID-19
- Authors
- Djordje AtanackovicStephanie V. AvilaForat LutfiDiego de Miguel-Perez16 more author(s)...
- Description
This dataset collected 40 ml of heparinized blood from 20 COVID-19 patients who were admitted to the University of Maryland Medical Center between June and August of 2020. Plasma samples were collected at a median of 10 or 7 days, dependent on the patient's risk group. Samples were analyzed using full-length recombinant protein in an enzyme-linked immunosorbent assay (ELISA). Antibodies were screened...
- Subject
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Antibodies, Neutralizing/immunologyAntibodies, Viral/immunologyCOVID-19/immunologyViral Proteins/immunology
- Timeframe
- 2020
- Access Rights
- Unrestricted access
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UMB Dataset
mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant
- Authors
- Etsuro NanishiMarisa E. McGrathTimothy R. O’MearaSoumik Barman17 more author(s)...
- Description
This study investigates multiple vaccine strategies to enhance immunogenicity and protection against SARS-CoV-2 in aged mice. The study aims to determine the effect of a booster dose, with an emphasis on older age. Female three and eleven-month-old BALB/c mice were studied over the course of 38 weeks. Mice received BNT162b2 SARS-CoV-2 spike mRNA vaccine series, primary vaccination series, and mock...
- Subject
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COVID-19/prevention & controlViral Vaccines/genetics
- Access Rights
- Unrestricted access
- Local Experts
- Matthew B. Frieman
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UMB Dataset
IFNa induces CCR5 in CD4+ T cells of HIV patients causing pathogenic elevation
- Authors
- Hélène Le BuanecValérie SchiavonMarine MerandetAlexandre How-Kit11 more author(s)...
- Description
This study analyzed samples from 73 healthy donors and 81 individuals with HIV, divided into Natural Viral Suppressors (NVS), untreated non-EC patients (UP), and treated patients (TP). Samples were collected from various sources and subjected to serological, phenotypic, and virological assessments. Peripheral blood mononuclear cells (PBMCs) were isolated, CD4+T cells were stimulated, and flow cytometry...
- Subject
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HIV Infections/therapy
- Access Rights
- Unrestricted access
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UMB Dataset
Relative contributions of various endogenous and exogenous factors to the mosquito microbiota
- Authors
- Haikel N. BogaleMatthew V. CannonKalil KeitaDenka Camara10 more author(s)...
- Description
Researchers used a high-throughput sequencing-based assay to characterize the bacterial composition and diversity of 665 individual field-caught mosquitoes, as well as their species, genotype at an insecticide resistance locus, blood-meal composition, and the eukaryotic parasites and viruses they carry. This data was used to rigorously estimate the individual effect of each parameter on the bacterial...
- Subject
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Pest Control, Biological
- Access Rights
- Unrestricted access
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UMB Dataset
Methylsulfonylmethane Increases the Alveolar Bone Density of Mandibles in Aging Female Mice
- Authors
- Hanan AljohaniLinda T. SenbanjoMohammed Al QraneiJoseph P. Stains1 more author(s)...
- Description
Thirty-six-week-old again female C5BL/6 mice were injected with MSM for thirteen weeks. Researchers examined the effects of MSM on bone density and development using micro-computed tomographic images, serum analyses, and immunohistochemical analyses.
- Subject
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Osteogenesis
- Access Rights
- Unrestricted access
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UMB Dataset
Mechanoactivation of NOX2-generated ROS elicits persistent TRPM8 Ca2+ signals that are inhibited by oncogenic KRas
- Authors
- Stephen J. PrattRachel M. LeeCakarina T. ChangErick O. Hernández-Ochoa11 more author(s)...
- Description
Human breast MCF10A epithelial cells were subjected to mechanical stimulation using glass pipettes on substrates with varying stiffness. Data on NOX2 or TRPM8 mRNA expression and its correlation with breast cancer patient outcomes were collected from the Kaplan–Meier Plotter database. Statistical analyses were performed using MATLAB.
- Subject
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Breast/pathology
- Access Rights
- Unrestricted access
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UMB Dataset
Approaches to Potentiated Neuroprotective Treatment in the Rodent Model of Ischemic Optic Neuropathy
- Authors
- Zara MehrabianYan GuoNeil R. MillerAmanda D. Henderson2 more author(s)...
- Description
Nonarthritic anterior ischemic optic neuropathy (NAION) commonly causes sudden optic nerve (ON)-related vision loss. The rodent NAION model (rAION) closely resembles NAION in presentation and physiological responses. Researchers hypothesized that blocking pro-inflammatory prostaglandin (PGE2) production by inhibiting monoacylglycerol lipase or cyclooxygenase activity and co-administering PGJ2 would...
- Subject
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Optic Nerve Diseases
- Timeframe
- 2021
- Access Rights
- Unrestricted access
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UMB Dataset
Refinement of a Live Attenuated Salmonella enterica Serovat Newport Vaccine with Improved Safety
- Description
Non-typhoidal Salmonella (NTS) is responsible for approximately 93 million cases of gastroenteritis annually. Little research has been directed towards a development of vaccines against Salmonella serogroups O:6,7 or O:8. Researchers constructed a live attenuated serogroup O:8 vaccine, CVS 1979, by deleting guaBA, htrA, and aroA from the genome of S. Newport. Over the course of 6 weeks, 6 to 8-week-old...
- Subject
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Salmonella VaccinesVaccine Development
- Access Rights
- Unrestricted access
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UMB Dataset
The optic nerve lamina region is a neural progenitor cell niche
- Authors
- Steven L. BernsteinYan GuoRebecca FawcettCandace Kerr3 more author(s)...
- Description
Tissue from the optic nerve lamina region (ONLR), were dissected from both mice and humans. Immunohistochemistry (IHC) was then performed on tissue sections, and Ki67 mitosis assays assessed cell proliferation. Cell cultivation techniques isolated and cultured cells from ONLR and optic nerve tissues. Further experiments induced cell differentiation and neurosphere formation. Transgenic animal studies...
- Subject
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Optic Nerve
- Access Rights
- Unrestricted accessApproval required