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- Optic Nerve Diseases 2
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UMB Dataset
Methylsulfonylmethane Increases the Alveolar Bone Density of Mandibles in Aging Female Mice
- Authors
- Hanan AljohaniLinda T. SenbanjoMohammed Al QraneiJoseph P. Stains1 more author(s)...
- Description
Thirty-six-week-old again female C5BL/6 mice were injected with MSM for thirteen weeks. Researchers examined the effects of MSM on bone density and development using micro-computed tomographic images, serum analyses, and immunohistochemical analyses.
- Subject
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Osteogenesis
- Access Rights
- Unrestricted access
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UMB Dataset
Prion Replication Environment Defines the Fate of Prion Strain Adaptation
- Authors
- Ilia V. BaskakovElizaveta KatorchaNuria Gonzalez-MontalbanNatallia Makarava1 more author(s)...
- Description
The research associated with this dataset explored cross-species prion transmission and the impact of cofactor environment on strain adaptation. Utilizing Protein Misfolding Cyclic Amplification with beads (PMCAb), hamster strain 263K was propagated under normal or RNA-depleted conditions first in mouse and then hamster substrates. A variety of readaptation experiments were conducted including brain...
- Subject
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Prion DiseasesZoonoses
- Access Rights
- Unrestricted access
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UMB Dataset
Tip60- and Sirtuin 2-Regulated MARCKS Acetylation and Phosphorylation Are Required for Diabetic Embryopathy
- Authors
- Penghua YangCheng XuE. Albert ReeceXi Chen5 more author(s)...
- Description
A high glucose level associated with maternal diabetes has been identified as a risk factor for fetal neural tube defects (NTD). The failure to successfully complete the complex neurulation process is possibly related to the loss of protection for cellular homeostasis resulting in organelle stress. Mitochondrial dysfunction and endoplasmic reticulum stress in the developing endothelium have been identified...
- Subject
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NeurulationPregnancy in Diabetics
- Access Rights
- Unrestricted access
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UMB Dataset
Region-Specific Response of Astrocytes to Prion Infection
- Authors
- Natallia MakaravaJennifer Chen-Yu ChangRajesh KushwahaIlia V. Baskakov
- Description
Chronic neuroinflammation is a common pathological hallmark of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, ALS, and prion disorders. Both reactive microgliosis and astrogliosis have been identified as having a role in the neuroinflammatory process. Studies of prion diseases of animals and humans have demonstrated activation and proliferation of microglia at the very early subclinical...
- Subject
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Neurodegenerative DiseasesPrion Diseases
- Access Rights
- Unrestricted access
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UMB Dataset
Approaches to Potentiated Neuroprotective Treatment in the Rodent Model of Ischemic Optic Neuropathy
- Authors
- Zara MehrabianYan GuoNeil R. MillerAmanda D. Henderson2 more author(s)...
- Description
Nonarthritic anterior ischemic optic neuropathy (NAION) commonly causes sudden optic nerve (ON)-related vision loss. The rodent NAION model (rAION) closely resembles NAION in presentation and physiological responses. Researchers hypothesized that blocking pro-inflammatory prostaglandin (PGE2) production by inhibiting monoacylglycerol lipase or cyclooxygenase activity and co-administering PGJ2 would...
- Subject
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Optic Nerve Diseases
- Timeframe
- 2021
- Access Rights
- Unrestricted access
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UMB Dataset
Biomarkers of lesion severity in a rodent model of nonarthritic anterior ischemic optic neuropathy (rNAION)
- Authors
- Yan GuoZara MehrabianMary A. JohnsonNeil R. Miller3 more author(s)...
- Description
The rodent model of nonarthritic anterior ischemic optic neuropathy (rNAION) is similar in many of its pathophysiological responses to clinical NAION. Like human NAION, there is significant variability in the severity of the lesion produced, and little is known of the parameters associated with rNAION induction severity or if pre- or early post-induction biomarkers can be identified that enable prediction...
- Subject
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Optic Nerve Diseases
- Access Rights
- Unrestricted access
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UMB Dataset
An optimized protocol for single nuclei isolation from clinical biopsies for RNA-seq
- Authors
- Thomas V. RousselleJennifer M. McDanielsAmol C. ShettyElissa Bardhi2 more author(s)...
- Description
Researchers present an optimized protocol for single nuclei RNA sequencing (snRNA-seq) that is fast, low, cost, and time effective due to the elimination of cell sorting and ultra-centrifugation. Both human and mouse tissue biopsies were assessed. Human kidney graft biopsies were collected from five kidney transplant recipients. Mouse needle biopsies were collected from heart, liver, kidney, spleen,...
- Subject
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High-Throughput Nucleotide Sequencing
- Access Rights
- Unrestricted access
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UMB Dataset
Refinement of a Live Attenuated Salmonella enterica Serovat Newport Vaccine with Improved Safety
- Description
Non-typhoidal Salmonella (NTS) is responsible for approximately 93 million cases of gastroenteritis annually. Little research has been directed towards a development of vaccines against Salmonella serogroups O:6,7 or O:8. Researchers constructed a live attenuated serogroup O:8 vaccine, CVS 1979, by deleting guaBA, htrA, and aroA from the genome of S. Newport. Over the course of 6 weeks, 6 to 8-week-old...
- Subject
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Salmonella VaccinesVaccine Development
- Access Rights
- Unrestricted access
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UMB Dataset
The optic nerve lamina region is a neural progenitor cell niche
- Authors
- Steven L. BernsteinYan GuoRebecca FawcettCandace Kerr3 more author(s)...
- Description
Tissue from the optic nerve lamina region (ONLR), were dissected from both mice and humans. Immunohistochemistry (IHC) was then performed on tissue sections, and Ki67 mitosis assays assessed cell proliferation. Cell cultivation techniques isolated and cultured cells from ONLR and optic nerve tissues. Further experiments induced cell differentiation and neurosphere formation. Transgenic animal studies...
- Subject
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Optic Nerve
- Access Rights
- Unrestricted accessApproval required
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UMB Dataset
Development of a Reproducible Swine Model of Chronic Ischemic Mitral Regurgitation: Lessons Learned
- Authors
- Chetan PasrijaRachael W. QuinnHani AlkhatibDouglas Tran7 more author(s)...
- Description
Thirty-five Yorkshire cross swine underwent percutaneous myocardial infarction with ethanol ablation of the circumflex or obtuse marginal (OM) arteries. Echocardiography was performed at various intervals to assess the development of ischemic mitral regurgitation (IMR) and cardiac function. Swine that developed significant IMR were scheduled for mitral valve operations, which were performed using cardiopulmonary...
- Subject
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Mitral Valve Insufficiency
- Access Rights
- Unrestricted access