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Development of a Reproducible Swine Model of Chronic Ischemic Mitral Regurgitation: Lessons Learned
UMB Dataset

UID: 218

Author(s): Chetan Pasrija*, Rachael W. Quinn, Hani Alkhatib, Douglas Tran, Daniel Bernstein, MaryJoe Rice, Ethan Koloff, David Morales, Michael N. D'Ambra, Mark R. Vesely, James S. Gammie * Corresponding Author
Thirty-five Yorkshire cross swine underwent percutaneous myocardial infarction with ethanol ablation of the circumflex or obtuse marginal (OM) arteries. Echocardiography was performed at various intervals to assess the development of ischemic mitral regurgitation (IMR) and cardiac function. Swine that developed significant IMR were scheduled for mitral valve operations, which were performed using cardiopulmonary bypass. Echocardiographic analysis was conducted to evaluate parameters such as ejection fraction, mitral regurgitation severity, and wall motion.
Subject of Study
Subject Domain
Access Restrictions
Unrestricted access
Access Instructions
All data is within the article and supplementary materials.
Associated Publications
Data Type
Equipment Used
Cook Medical micropuncture sheath
GE OEC 9800 Plus machine
Philips iE33 ultrasound system
Philips X5 probe
Philips X7-2t probe
Pressure Products SafeSheath
Study Type
Dataset Format(s)
Microsoft Word, jpg
Data Collection Instruments
Kruskal-Wallis test
Fisher's exact test
Dataset Size