UMB Data Catalog
A project of the Health Sciences and Human Services LibraryBiomarkers of lesion severity in a rodent model of nonarthritic anterior ischemic optic neuropathy (rNAION)
UMB Dataset
UID: 208
- Description
- The rodent model of nonarthritic anterior ischemic optic neuropathy (rNAION) is similar in many of its pathophysiological responses to clinical NAION. Like human NAION, there is significant variability in the severity of the lesion produced, and little is known of the parameters associated with rNAION induction severity or if pre- or early post-induction biomarkers can be identified that enable prediction of lesion severity and ultimate loss of retinal ganglion cells (RGCs). Adult male Sprague-Dawley outbred rats were evaluated for various parameters including physiological characteristics (heart rate, respiratory rate, temperature, hematocrit [Hct]), optic nerve head (ONH) appearance, pre- and post-induction mean diameter, and intravenous fluorescein and indocyanine green angiographic patterns of vascular leakage at 5 hours post-induction, performed using a spectral domain-optical coherence tomography (SD-OCT) instrument.
Male
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Access via Figshare
Datatable and images
Access via ArticleDatatables, images, and figures
- Access Restrictions
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Unrestricted access
- Access Instructions
- Data available at Figshare and in article
- Associated Publications
- Data Type
- Equipment Used
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deltaphase padFluoresceinindocyanine greenmethylcellulose eyedropsrat fundus contact lensSD-OCT 25-diopter adapter lenswarming pads
- Software Used
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Stereo Investigator 10
- Study Type
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Interventional
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