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Circadian Rest-Activity Rhythms in Children with Leukemia on Dexamethasone
UMB Dataset

UID: 90

Author(s): Valerie E. Rogers*, Belinda Mandrell * Corresponding Author
Description
This study measured circadian activity rhythms (CAR) and fatigue in children and adolescents with acute lymphoblastic leukemia on maintenance chemotherapy during the 5 days prior to a pulse of dexamethasone and the 5 days after the start of dexamethasone. CAR was measured via an actigraph worn continuously for 10 days. Fatigue was measured at 4 time points. The fatigue measures used for this study were Fatigue Scale-Child, Fatigue Scale-Adolescent and Fatigue Scale-Parent. The aims of this descriptive study were to compare CAR during the periods before and during dexamethasone therapy, and to explore the hypothesis that less robust CAR was associated with greater fatigue.
Timeframe
2001 - 2006
Geographic Coverage
Houston (Tex.)
Memphis (Tenn.)
Toronto (Ont.)
Subject of Study
Human
Subject Domain
Circadian Rhythm
Dexamethasone
Leukemia
Population Age
Child (2 years to 12 years)
Adolescent (13 years to 18 years)
Subject Gender
Female
Male
Keywords
Actigraphy
Acute lymphoblastic leukemia
Cancer
Chemotherapy
Circadian Activity Rhythm
Fatigue
Pediatric Oncology
Sleep
Access via Open Science Framework (OSF)

https://doi.org/10.17605/OSF.IO/3W7YV

Access Restrictions
Unrestricted access
Access Instructions
Available via the Open Science Framework (OSF)
Associated Publications
Hinds PS, Hockenberry MJ, Gattuso JS, et al. (2007). Dexamethasone alters sleep and fatigue in pediatric patients with acute lymphoblastic leukemia. Cancer. Nov 15 2007;110(10):2321-2330. DOI: https://doi.org/10.1002/cncr.23039
Sanford, S. D., Okuma, J. O., Pan, J., Srivastava, D. K., West, N., Farr, L., Hinds, P. S. (2008). Gender differences in sleep, fatigue, and daytime activity in a pediatric oncology sample receiving dexamethasone. Journal of Pediatric Psychology, 2008;33(3):298-306. DOI: https://doi.org/10.1093/jpepsy/jsm110
Vallance, K., Liu, W., Mandrell, B. N., Panetta, J. C., Gattuso, J. S., Hockenberry, M., Zupanec, S., Yang, L., Yang, J., Hinds, P. S. (2010) Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL. European Journal of Cancer, 2010:46:1848-55. DOI: http://dx.doi.org/10.1016/j.ejca.2010.03.026
Vallance, K., Yang, J., Li, J., Crabtree, V. M., Hinds, P. S., Mandrell, B. N. (2011) Disturbed sleep in pediatric patients with leukemia: the potential role of interleukin-6 (-174GC) and tumor necrosis factor (-308GA) polymorphism. Oncology Nursing Forum, 2011:38(5):E365-E372. DOI: http://dx.doi.org/10.1188/11.ONF.E365-E372
Rogers, V.E., Zhu, S., Ancoli-Israel, S., Hinds, P.S. (2014). Impairment in circadian activity rhythms occurs during dexamethasone therapy in children with leukemia. Pediatric Blood & Cancer, 61, 1986-1991. PMID 25066691 DOI: http://doi.org/10.1002/pbc.25147
Data Type
Statistical
Clinical Measures
Demographic
Equipment Used
Micromini Actigraph

Battery-operated accelerometer measures movement over time and transduces these data into activity counts

Study Type
Observational
Dataset Format(s)
Microsoft Excel, Microsoft Word, SPSS