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  • Sleep Disturbances in Neurobehaviorally Challenged Children with Sickle Cell Disease
    UMB Dataset

    Authors
    Valerie E. Rogers
    Eboni I. Lance
    Description

    Children with sickle cell disease (SCD) experience neurodevelopmental decline over time. They also tend to have short duration, poor quality sleep and elevated fatigue levels. This study measured sleep via actigraphy over one week and cognitive and behavioral measures in 19 children and adolescents with SCD. Aged 7-18 years, the majority of participants were referred for neurodevelopmental testing due to academic or behavioral difficulties. Data was collected from parent report, medical record, and included age, sex, race, SCD genotype, results of neuroimaging studies including brain magnetic resonance imaging (MRI) and transcranial Doppler (TCD) velocities, and current use of hydroxyl urea or chronic blood transfusion. Additionally, parents completed the Behavior Rating Inventory of Executive Function (BRIEF), participants completed the Wide Range Achievement Test (WRAT), and both completed the PedsQL Multidimensional Fatigue Scale.

    Subject
    Anemia, Sickle Cell
    Neurodevelopmental Disorders
    Sleep Wake Disorders
    Access Rights
    Unrestricted access
  • Sleep, circadian rhythms and fatigue in children with CNS tumors hospitalized for high dose chemotherapy
    UMB Dataset

    Authors
    Valerie E. Rogers
    Belinda Mandrell
    Description

    This study tested a sleep promotion intervention (randomized controlled trial) in children with recently diagnosed central nervous system tumors admitted to the hospital for high dose chemotherapy in preparation for autologous stem cell rescue. We hypothesized that disturbed sleep of hospitalized pediatric oncology patients would be reduced by altering the hospital sleep environment. Therefore, a randomized, attention-controlled sleep intervention was implemented in children and adolescents with central nervous system tumors admitted for 6 days for high dose chemotherapy prior to stem cell transplant. Children and adolescents diagnosed with medulloblastoma or histologically similar tumor, 4 to 19 years and their parent were recruited over 3 years.Questionnaires used to gather the data were: Fatigue Scale-Child, Fatigue Scale-Adolescent, Fatigue Scale-Parent. Data was also obtained using actigraphy.

    Subject
    Central Nervous System/Cancer
    Sleep Wake Disorders
    Geographic Coverage
    United States
    Access Rights
    Unrestricted access
  • Circadian rhythms, fatigue and bright light therapy in adolescent cancer survivors
    UMB Dataset

    Authors
    Valerie E. Rogers
    Description

    This 2-phase study explored the differences in sleep and circadian activity rhythms between adolescents who were within 5 years of completing treatment for any type of cancer and healthy, age-matched controls; and trialed a morning bright light therapy intervention to gather preliminary evidence of its safety, feasibility and outcomes.

    Subject
    Cancer Survivors
    Sleep Wake Disorders
    Geographic Coverage
    United States
    Access Rights
    Registration required
  • Circadian Rest-Activity Rhythms in Children with Leukemia on Dexamethasone
    UMB Dataset

    Authors
    Valerie E. Rogers
    Belinda Mandrell
    Description

    This study measured circadian activity rhythms (CAR) and fatigue in children and adolescents with acute lymphoblastic leukemia on maintenance chemotherapy during the 5 days prior to a pulse of dexamethasone and the 5 days after the start of dexamethasone. CAR was measured via an actigraph worn continuously for 10 days. Fatigue was measured at 4 time points. The fatigue measures used for this study were Fatigue Scale-Child, Fatigue Scale-Adolescent and Fatigue Scale-Parent. The aims of this descriptive study were to compare CAR during the periods before and during dexamethasone therapy, and to explore the hypothesis that less robust CAR was associated with greater fatigue.

    Subject
    Circadian Rhythm
    Dexamethasone
    Leukemia
    Geographic Coverage
    Canada
    United States
    Access Rights
    Unrestricted access