Description: Periodic limb movements in sleep (PLMS) are associated with sleep fragmentation and sympathetic nervous system activation, which in turn have been linked to cognitive and behavioral deficits in children and cardiovascular morbidity in both adults and children. Emerging evidence indicates that many children with sickle cell disease (SCD) have elevated PLMS. The specific aims of this prospective, repeated-measures, descriptive study were to assess the agreement between PLMS measurement by actigraphy and concurrent polysomnography (PSG), to test the feasibility of measuring PLMS by actigraphy at home, to evaluate PLMS variability over consecutive nights by actigraphy, and to provide preliminary data on objective and subjective correlates of PLMS. Twenty children with SCD and restless legs syndrome (RLS) symptoms or polysomnography-documented PLMS underwent concurrent attended polysomnography and ankle activity monitoring over one to two nights and home activity monitoring for three nights. Serum iron and ferritin were measured pre- and post-polysomnography. The datasets associated with this study include demographic data, SCD subtype, polysomnographic/activity monitor values, medical history, and clinical measures.
Timeframe: 2010 - 2011
Geographic Coverage: Philadelphia (Pa.)

Subject of Study

Subject Domain

Population Age

Child (2 years to 12 years)

Adolescent (13 years to 18 years)

Subject Gender

Female

Male

Keywords