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Results Found: 23
  • Penicillin Skin Testing in Methicillin-Sensitive Staphylococcus aureus Bacteremia: A Cost-Effectiveness Analysis
    UMB Dataset

    Authors
    Todd Joseph Mattingly, II
    Stephen Meninger
    Emily L. Heil
    Description

    Beta-lactams provide superior outcomes in comparison to vancomycin in treating methicillin-susceptible Staphylococcus aureus (MSSA) infections complicated by bacteremia. However, approximately 11% of inpatients report a penicillin (PCN) allergy when it is estimated that only 1% of the general population is truly allergic to the antibiotic. Consequently, many patients may be receiving suboptimal treatment for a serious infection with a high mortality rate. This study evaluated the cost-effectiveness of penicillin skin testing (PST) in adult inpatients self-reporting PCN allergy and undergoing treatment for MSSA bacteremia. A decision analytic model was developed comparing an acute care PST intervention to a scenario with no confirmatory allergy testing. This dataset includes a decision analytic model diagram, model inputs, and an Excel file with MSSA bacteremia model parameters and probabilistic simulation calculations.

    Subject
    Bacteremia
    Models, Econometric
    Skin Tests/economics
    Staphylococcus aureus
    Access Rights
    Free to All
  • Availability of Study Protocols for Randomized Trials Published in High-Impact Medical Journals: A Cross-Sectional Analysis
    UMB Dataset

    Authors
    Peter Doshi
    O'Mareen Spence
    Kyungwan Hong
    Richie Onwuchekwa Uba
    Description

    To improve reporting transparency and research integrity, some journals have begun publishing study protocols and statistical analysis plans alongside trial publications. To determine the overall availability and characteristics of protocols and statistical analysis plans this study reviewed all randomized clinical trials (RCT) published in 2016 in the following 5 general medicine journals: Annals of Internal Medicine, BMJ, JAMA, Lancet, and NEJM. Characteristics of RCTs were extracted from the publication and clinical trial registry. A detailed assessment of protocols and statistical analysis plans was conducted in a 20% random sample of trials. Dataset contains extraction sheets (as SAS data files), code to calculate the values in the tables in the manuscript, and a supplemental file with additional notes on methods used in the study.

    Subject
    Randomized Controlled Trials as Topic
    Access Rights
    Free to All
  • Assessment of the Real-World Safety Profile of Vedolizumab Using the United States Food and Drug Administration Adverse Event Reporting System
    UMB Dataset

    Authors
    Raymond K. Cross
    Michael Chiorean
    Francis Vekeman
    Yongling Xiao
    3 more author(s)...
    Description

    For two decades the standard drug therapy for patients with Crohn’s disease (CD) and ulcerative colitis (UC) has been anti-tumor necrosis factor agents (anti-TNFs) such as adalimumab (Humira), certolizumab pegol (Cimzia), infliximab (Remicade) and several others. More recently, vedolizumab (Entyvio) has entered the market as the first gut-selective integrin blocker that offers an alternative treatment for inflammatory bowel disease (IBD). Using the FDA Adverse Event Reporting System (FAERS) database, this study compared adverse event reports (AE) for the two types of therapies. The search retrieved 499 reports for vedolizumab and 119,620 for anti-TNFs for the years 1998 through 2015. Using the proportional reporting ratio (PPR) and the empirical Bayesian geometric mean (EBGM) algorithms, AE data were reviewed for signals of disproportionate reporting for the two types of drugs. This dataset includes statistical summary tables of characteristics (demographic) and a variety of adverse event comparisons of vedolizumab, anti-TNFs, and all other medications. Cleaned FAERS data was provided with permission by DrugLogic, Inc. Interested researchers may contact DrugLogic Inc. (Reston, VA) by calling 800-393-1313 or emailing swordham@druglogic.com

    Subject
    Colitis, Ulcerative/drug therapy
    Crohn Disease/drug therapy
    Drug-Related Side Effects and Adverse Reactions
    Access Rights
    Access to cleaned, mapped, de-duplicated and normalized raw FAERS data requires permission of DrugLogic, Inc.
  • Heroin in Transition Study (HIT)
    UMB Dataset

    Authors
    Daniel Ciccarone
    George J. Unick
    Jenny K. Cohen
    Sarah G. Mars
    1 more author(s)...
    Description

    Dataset comprises hospitalization rates for opioid injection-related skin and soft-tissue infections (O-SSTI) correlated with changes in the price and purity of heroin for the years 1993 through 2010, inclusive. Data is derived from the Healthcare Cost and Utilization Project (HCUP) Nationwide Inpatient Sample (NIS) and the Drug Enforcement Administration (DEA) System to Retrieve Information from Drug Evidence (STRIDE) databases for 27 Metropolitan Statistical Areas (MSAs).

    Subject
    Substance-Related Disorders
    Geographic Coverage
    United States
  • US Regional and Demographic Differences in Prescription Opioid and Heroin-Related Overdose Hospitalizations
    UMB Dataset

    Authors
    George J. Unick
    Daniel Ciccarone
    Description

    Dataset is comprised of heroin overdose-related and prescription opioid overdose-related hospitalization rates for the years 2000 through 2014. Data is derived from the Healthcare Cost and Utilization Project (HCUP) Nationwide Inpatient Sample (NIS). Included are rates by census region and division with separate rates for age and race.

    Subject
    Substance-Related Disorders
    Geographic Coverage
    United States
  • National Survey of State Medicaid Psychotropic-Monitoring Programs Targeting Youth
    UMB Dataset

    Authors
    Susan dosReis
    Ming-Hui Tai
    Wendy Castillo Camelo
    Gloria Reeves
    Description

    Officials from Medicaid programs in all 50 states and the District of Columbia were invited to participate in a telephone survey assessing psychotropic-monitoring programs targeting youth. 38 completed the survey which was administered between August 2011 and December 2012. This dataset includes information about program characteristics, implementation strategies, review agency, professional oversight, periodic review, psychotropic drug class, concomitant use, and prescriber credentials.

    Subject
    Medicaid
    Psychotropic Drugs
    Geographic Coverage
    United States
  • Psychotropic Polypharmacy Among Youths With Serious Emotional and Behavioral Disorders Receiving Coordinated Care Services
    UMB Dataset

    Authors
    Susan dosReis
    Benjamin Wu
    Eric J. Bruns
    Ming-Hui Tai
    2 more author(s)...
    Description

    This dataset represents a comparison of polypharmacy among youth with serious emotional and behavioral disorders enrolled in coordinated care services (CCS) versus those receiving traditional mental health services. Data were extracted from Medicaid administrative claims (demographic, diagnosis by ICD-9 code, procedure codes, and psychotropic medication), child welfare administrative records, and juvenile justice records. The final analytic sample included a total of 814 CCS youths and 993 in the traditional care cohort.

    Subject
    Child Behavior Disorders
    Medicaid
    Psychotropic Drugs
    Geographic Coverage
    Maryland
  • Antipsychotic Treatment Among Youth in Foster Care
    UMB Dataset

    Authors
    Susan dosReis
    Yesel Yoon
    David M. Rubin
    Mark A. Riddle
    2 more author(s)...
    Description

    Data from Medicaid fee-for-service and managed care claims from one Mid-Atlantic state were analyzed for this cross-sectional study. The dataset consists of a total of 16,969 youths under the age of 20 with a mental health diagnosis and a pharmacy claim for antipsychotic medication in 2003. Data for each individual includes demographic, Medicaid program category (ie, foster care, disabled), psychiatric diagnostic codes, and psychotropic medications by major therapeutic class.

    Subject
    Child, Foster
    Medicaid
    Psychotropic Drugs
    Timeframe
    2003
  • Mental Health Services for Youths in Foster Care and Disabled Youths
    UMB Dataset

    Authors
    Susan dosReis
    Julie Magno Zito
    Daniel J. Safer
    Karen L. Soeken
    Description

    Data were extracted from a review of computerized administrative claims for 15,507 Medicaid youth in an effort to assess differences in rates of mental health treatment for enrollees in one of 3 categories of aid. The study population consisted of individuals aged 0-19 years residing in a suburban county in a mid-Atlantic state during 1996 and enrolled in the fee-for-service Medicaid program. Mental health services were analyzed and compared for youth in foster care, receiving Supplemental Security Income (SSI), and all other forms of assistance such as Aid to Families with Dependent Children (AFDC). The dataset includes demographic information, type of mental health services provided, mental disorder diagnoses (in 15 subcategories), as well as psychotropic and certain nonpsychotropic medications prescribed.

    Subject
    Child, Foster
    Medicaid
    Timeframe
    1996
  • Intertwined Epidemics: National Demographic Trends in Hospitalizations for Heroin- and Opioid-Related Overdoses, 1993-2009
    UMB Dataset

    Authors
    George J. Unick
    Daniel Rosenblum
    Sarah G. Mars
    Daniel Ciccarone
    Description

    This study investigated demographic trends over time in the use of prescription opioids versus heroin among addicted individuals. ICD9 codes associated with hospitalizations for overdoses from either prescription opioids (POD) or heroin (HOD) were harvested from the Nationwide Inpatient Sample (NIS) for the years 1993 through 2009, inclusive. Population data were taken from U.S. Census statistics. Demographic specific rates of POD and HOD hospital admissions were analyzed to determine if fluctuations in the dynamics of one form of opiate, such as supply-based reduction, are correlated with changes in the rates of overdoses of the other. Dataset includes statistical and demographic data.

    Subject
    Substance-Related Disorders
    Geographic Coverage
    United States

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