UMB Data Catalog

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UMB Dataset

Biomarkers of Airway Inflammation and Asthma Control in Children with Comorbid Sleep-Disordered Breathing

UID: 91
Author(s): Valerie E. Rogers*, Mary E. Bollinger, Mohan E. Tulapurkar, Shijun Zhu, Jeffrey D. Hasday...
* Corresponding Author
Description
A bi‐directional relationship exists between asthma and obstructive sleep apnea (OSA) in which presence of one is associated with increased prevalence and severity of the other. This study was undertaken to determine if OSA accounted for differences in airway and systemic inflammation in asthmatic children and if inflammation was associated with asthma control. 27 non-obese children aged 4-12 years with persistent asthma, with or without OSA, were recruited for the research. Asthma control was measured with the Childhood Asthma Control Test. Participants underwent polysomnography and blood sampling, and those with OSA also underwent clinically indicated adenotonsillectomy. Tonsils and sera were analyzed for 11 cytokines. The dataset includes demographic data, health history, spirometry/polysomnographic measures, and immunoassay values.
Timeframe
2014 - 2017
Subject of Study
Subject Domain
Asthma
Inflammation
Sleep Wake Disorders
Population Age
Child (2 years to 12 years)
Subject Gender
Female
Male
Keywords
Comorbidity
Cytokines
Sleep Apnea, Obstructive
Spirometry

Access

Restrictions
Unrestricted access
Instructions
Available via the Open Science Framework (OSF)
Associated Publications
Rogers VE, Bollinger ME, Tulapurkar ME, et al. (2018) Inflammation and Asthma Control in Children with Comorbid Obstructive Sleep Apnea. Pediatric Pulmonology, 53, 1200-1207. DOI: 10.1002/ppul.24074
Data Type
Statistical
Clinical Measures
Demographic
Equipment Used
Luminex 100 Flow Cytometry Analyzer System

Multiplexing up to 100 analytics in a single well of a microtitre plate

Milliplex Human Cytokine Multiplex Immunoassay Kit

Analyze multiple cytokine biomarkers using the Luminex technology in human serum, plasma and cell culture samples

Software Used
Bio-Plex Software

Provides system control, validation, calibration, data acquisition, and data analysis for multiplex assays

SPSS, v. 21

Comprehensive set of statistical tools

Study Type
Observational
Dataset Format(s)
Microsoft Excel, Microsoft Word, SPSS
Data Collection Instruments
Paediatric Sleep Questionnaire (PSQ)
Childhood Asthma Control Test (cACT)
Grant Support
RC-307793/American Lung Association
Internal Funding/University of Maryland School of Nursing
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