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- Amish 2
- Ctenocephalides 2
- Anemia, Sickle Cell 1
- COVID-19 1
- Craniomandibular Disorders 1
- Epidemiology 1
- Ethnic Groups/genetics 1
- Facial Pain 1
- Gene Expression Profiling 1
- Genetics, Population 1
- Genome 1
- Glucose/metabolism 1
- Health Status Indicators 1
- Hearing Loss 1
- Heart Disease Risk Factors 1
- Immunity 1
- Influenza in Birds 1
- Influenza, Human 1
- Neurodevelopmental Disorders 1
- Optic Nerve 1
- Point Mutation 1
- Rickettsia typhi 1
- Risk Factors 1
- Siphonaptera 1
- Sleep Wake Disorders 1
- Tendon Injuries 1
- Transcription, Genetic 1
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UMB Dataset
Analysis of Rickettsia typhi-Infected and Uninfected Cat Flea (Ctenocephalides felis) Midgut cDNA Libraries: Deciphering Molecular Pathways Involved in Host Response to R. typhi Infection
- Authors
- Abdu F. AzadSheila M. Dreher-LesnickShane M. CeraulSky C. Lesnick4 more author(s)...
- Description
Murine typhus is a febrile disease caused by the bacterium, Rickettsia typhi (R. typhi), and transmitted via infected fleas. This study investigated midgut responses of infected versus uninfected cat fleas (Ctenocephalides felis) by constructing cDNA libraries and examining transcript levels. Select C. felis serine proteases, GTPases and defense response genes were compared to identify differences...
- Subject
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CtenocephalidesGene Expression ProfilingRickettsia typhiTranscription, Genetic
- Timeframe
- 2009
- Access Rights
- Unrestricted access
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UMB Dataset
Complete mitochondrial genome of the cat flea, Ctenocephalides felis
- Authors
- Joseph J. GillespieVictoria I. VerhoeveMariah L. PlumerTimothy P. Driscoll2 more author(s)...
- Description
With over 2,500 identified species across the globe, fleas are notorious veterinary pests and vectors of pathogens, including Rickettsia typhi (murine typhus), R. felis (murine typhus-like illness), Bartonella henselae (cat-scratch disease), and myxoma virus (Myxomatosis). Speciation of fleas is reliant on distinguishing morphological features; however, studies have also used certain mitochondrial...
- Subject
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CtenocephalidesGenomeSiphonaptera
- Access Rights
- Unrestricted access
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UMB Dataset
Control of Glucose Metabolism is Important in Tenogenic Differentiation of Progenitors Derived From Human Injured Tendons
- Authors
- Soutarou IzumiSatoru OtsuruNobuo AdachiNgozi Akabudike1 more author(s)...
- Description
Glucose metabolism is altered in injured and healing tendons. However, the mechanism by which it is involved in the pathogenesis of the tendon healing process remains unclear. Injured tendons do not completely heal and often induce fibrous scar and chondroid lesion. Connective tissue progenitor cells appear in injured tendons and can contribute to healing and chondroid degeneration. Using metabolomic...
- Subject
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Glucose/metabolismTendon Injuries
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UMB Dataset
Strain-specific alterations in gut microbiome and host immune responses elicited by tolerogenic Bifidobacterium pseudolongum
- Authors
- Bing MaSamuel J. GavzyVikas SaxenaYang Song12 more author(s)...
- Description
To determine strain-specific driving mechanisms of B. pseudolongum UMB-MBP-01, researchers compared it to porcine tropic strain B. pseudolongum ATCC25526 using cell culture and in vivo experimentation and comparative genomic approaches. The data demonstrates that these two strains possess distinct genetic repertoires in carbohydrate assimilation, differential activation signatures and cytokine responses...
- Subject
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Immunity
- Access Rights
- Unrestricted access
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UMB Dataset
Amish Complex Genetic Disease Database
- Description
The Amish Research Group of the University of Maryland School of Medicine has been studying the Old Order Amish population in Lancaster County, PA, since 1993. This database currently consists of health-related data on over 7,000 adults resulting from studies ranging from population and basic science to clinical and translational research. Areas of investigation include: Cardiovascular Risk, Diabetes,...
- Subject
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AmishEthnic Groups/geneticsGenetics, PopulationHealth Status Indicators
- Access Rights
- Approval required
- Local Experts
- Alan R. ShuldinerBraxton C. Mitchell
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Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA)
- Alternate Title(s)
- OPPERA
- Description
This dataset is the result of a multi-center, 7 year prospective investigation into the biopsychosocial, environmental, and genetic risk factors associated with the onset and persistence of temporomandibular disorders (TMD). The OPPERA project consisted of 4 observational studies: a prospective cohort study of first-onset TMD, a baseline case-control study of chronic TMD, a matched case-control study...
- Subject
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Craniomandibular DisordersFacial PainRisk Factors
- Access Rights
- Approval requiredRegistration required
- Local Experts
- Joel D. GreenspanMeg JohantgenShijun ZhuSusan G. Dorsey
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UMB Dataset
Sleep Disturbances in Neurobehaviorally Challenged Children with Sickle Cell Disease
- Authors
- Valerie E. RogersEboni I. Lance
- Description
Children with sickle cell disease (SCD) experience neurodevelopmental decline over time. They also tend to have short duration, poor quality sleep and elevated fatigue levels. This study measured sleep via actigraphy over one week and cognitive and behavioral measures in 19 children and adolescents with SCD. Aged 7-18 years, the majority of participants were referred for neurodevelopmental testing...
- Subject
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Anemia, Sickle CellNeurodevelopmental DisordersSleep Wake Disorders
- Access Rights
- Unrestricted access
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UMB Dataset
The optic nerve lamina region is a neural progenitor cell niche
- Authors
- Steven L. BernsteinYan GuoRebecca FawcettCandace Kerr3 more author(s)...
- Description
Tissue from the optic nerve lamina region (ONLR), were dissected from both mice and humans. Immunohistochemistry (IHC) was then performed on tissue sections, and Ki67 mitosis assays assessed cell proliferation. Cell cultivation techniques isolated and cultured cells from ONLR and optic nerve tissues. Further experiments induced cell differentiation and neurosphere formation. Transgenic animal studies...
- Subject
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Optic Nerve
- Access Rights
- Unrestricted accessApproval required
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GISAID
- Alternate Title(s)
- Global Initiative on Sharing All Influenza Data
- Description
"The GISAID Initiative promotes the rapid sharing of data from all influenza viruses and the coronavirus causing COVID-19. This includes genetic sequence and related clinical and epidemiological data associated with human viruses, and geographical as well as species-specific data associated with avian and other animal viruses, to help researchers understand how viruses evolve and spread during epidemics...
- Subject
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COVID-19Influenza in BirdsInfluenza, Human
- Access Rights
- Unrestricted access
- Local Experts
- Davide ZellaFrancesca BenedettiRobert C. Gallo
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UMB Dataset
Prevalence, Control, and Treatment of Diabetes, Hypertension, and High Cholesterol in the Amish
- Authors
- Braxton C. MitchellShisi HeKathleen A. RyanElizabeth A. Streeten11 more author(s)...
- Description
Diabetes, hypertension, and hypercholesterolemia are three of the major risk factors for the development of cardiovascular disease (CVD), a leading cause of death in the United States. The burden of these disorders is not uniform across the country primarily due to socioeconomic status, cultural practices, and lifestyle. To evaluate the effect of these disparities, this study compared the prevalence...
- Subject
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AmishEpidemiologyHeart Disease Risk Factors