UMB Data Catalog

UMB Dataset

Authors: Zara Mehrabian

Yan Guo

Neil R. Miller

Amanda D. Henderson

2 more author(s)...
Description: Nonarthritic anterior ischemic optic neuropathy (NAION) commonly causes sudden optic nerve (ON)-related vision loss. The rodent NAION model (rAION) closely resembles NAION in presentation and physiological responses. Researchers hypothesized that blocking pro-inflammatory prostaglandin (PGE2) production by inhibiting monoacylglycerol lipase or cyclooxygenase activity and co-administering PGJ2 would...
Subject: Optic Nerve Diseases
Timeframe: 2021
Access Rights: Unrestricted access

UMB Dataset

Authors: Yan Guo

Zara Mehrabian

Mary A. Johnson

Neil R. Miller

3 more author(s)...
Description: The rodent model of nonarthritic anterior ischemic optic neuropathy (rNAION) is similar in many of its pathophysiological responses to clinical NAION. Like human NAION, there is significant variability in the severity of the lesion produced, and little is known of the parameters associated with rNAION induction severity or if pre- or early post-induction biomarkers can be identified that enable prediction...
Subject: Optic Nerve Diseases
Access Rights: Unrestricted access

UMB Dataset

Authors: Thomas V. Rousselle

Jennifer M. McDaniels

Amol C. Shetty

Elissa Bardhi

2 more author(s)...
Description: Researchers present an optimized protocol for single nuclei RNA sequencing (snRNA-seq) that is fast, low, cost, and time effective due to the elimination of cell sorting and ultra-centrifugation. Both human and mouse tissue biopsies were assessed. Human kidney graft biopsies were collected from five kidney transplant recipients. Mouse needle biopsies were collected from heart, liver, kidney, spleen,...
Subject: High-Throughput Nucleotide Sequencing
Access Rights: Unrestricted access

UMB Dataset

Description: Non-typhoidal Salmonella (NTS) is responsible for approximately 93 million cases of gastroenteritis annually. Little research has been directed towards a development of vaccines against Salmonella serogroups O:6,7 or O:8. Researchers constructed a live attenuated serogroup O:8 vaccine, CVS 1979, by deleting guaBA, htrA, and aroA from the genome of S. Newport. Over the course of 6 weeks, 6 to 8-week-old...
Subject: Salmonella Vaccines

Vaccine Development
Access Rights: Unrestricted access

Alternate Title(s): OAI
Description: Four clinical centers participated in this 11 year, prospective observational study of knee osteoarthritis. The goal of the research was to identify biochemical, genetic, and imaging biomarkers associated with the development and progression of osteoarthritis. Evaluation of the cumulative data in comparison with structural and/or clinical outcomes is expected to provide insights into the prevention...
Subject: Osteoarthritis

Osteoarthritis, Knee

Osteoarthritis/epidemiology
Access Rights: Registration required
Local Experts: Qoot Alkhubaizi