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Osteoarthritis Initiative

Alternate Titles(s): OAI

UID: 41

Description
Four clinical centers participated in this 11 year, prospective observational study of knee osteoarthritis. The goal of the research was to identify biochemical, genetic, and imaging biomarkers associated with the development and progression of osteoarthritis. Evaluation of the cumulative data in comparison with structural and/or clinical outcomes is expected to provide insights into the prevention and treatment of the disease. Over the course of the study, data were collected from 4,796 subjects from over 431,000 clinical and imaging visits resulting in close to 26,626,000 images in the archive. Multiple datasets from this research include: Participant Information (demographic & cohort, measures inventory, outcomes); AllClinical Dataset (multiple datasets with subject risk factors, joint symptom/function, medical history, physical exam, nutrition, & biomarkers (summary of phlebotomy and urine specimen collection times)); Medication Inventory; Knee MR Image Assessments (quantitative cartilage morphometry, semi-quantitative scoring); Knee MRI Metaanalysis; Knee X-Ray Image Assessments; Knee X-Ray Metaanalysis; FNIH Project (post-processed OAI image data as well as serum and urine evaluations from a subset of one of the cohorts); Ancillary Studies (accelerometry measurements, Bone Quality MRI and DEXA measurements, Pivotal OAI MRI Analyses (POMA), and Skin Auto-Fluorescence (Sage) measurements).
Timeframe
2004 - 2015
Local Experts
Qoot Alkhubaizi
Subject of Study
Human
Subject Domain
Osteoarthritis
Osteoarthritis, Knee
Osteoarthritis/epidemiology
Population Age
Adult (19 years to 64 years)
Senior (65 years to 79 years)
Subject Gender
Female
Male
Access via National Institute of Mental Health Data Archive (NDA)

Permanent archive of all data from the OAI

Access Restrictions
Registration required
Access Instructions
Available from the NIMH Data Archive site. Must create a user account and register for access.
Data Type
Clinical Measures
Demographic
Digital Images
Study Type
Observational
Dataset Format(s)
SAS, ASCII