Filter by
- Bacterial Proteins/metabolism 1
- Brachyura 1
- Brachyura/genetics 1
- Cell- and Tissue-Based Therapy/methods 1
- Disease Transmission, Infectious 1
- Gastrointestinal Microbiome 1
- Genome-Wide Association Study 1
- Genomics 1
- High-Throughput Nucleotide Sequencing 1
- Immunity 1
- Intensive Care Units 1
- Invertebrate Hormones/genetics 1
- Methicillin-Resistant Staphylococcus aureus 1
- Multifactorial Inheritance 1
- Neuropeptides 1
- Pest Control, Biological 1
- Plasmodium falciparum/genetics 1
- RNA-Binding Proteins / chemistry 1
- RNA-Binding Proteins/antagonists & inhibitors 1
- Sequence Analysis, RNA 1
- Sexual Maturation 1
- Shigella 1
- Transcriptome 1
- Whole Genome Sequencing 1
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UMB Dataset
Dynamics of the Gut Microbiome in Shigella-Infected Children During the First Two Years of Life
- Authors
- Esther NdungoJohanna B. HolmSyze GamaAndrea G. Buchwald4 more author(s)...
- Description
This dataset was used to overview the taxonomic composition of the gastrointestinal microbiomes during the first two years of life with the intent to better understand the effects of the invasive pathogen, Shigella. Data was collected through a two year longitudinal study of a mother-infant cohort in Malawi, using 16S rRNA amplicon sequencing to characterize the gastrointestinal microbiota. Rectal...
- Subject
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Gastrointestinal MicrobiomeGenomicsShigella
- Access Rights
- Unrestricted access
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UMB Dataset
Neuropeptide identification using eyestalk-RNAseq of red deep-sea crab, Chaceon quenquedens
- Authors
- Shadaesha GreenTsvetan BachvaroffJ. Sook Chung
- Description
This study aimed to understand the role of eyestalk neuropeptides in vitellogenesis. Molt-inhibiting hormone (MIH) and crustacean hyperglycemic hormone (CHH) cDNA sequences were first isolated from the eyestalk ganglia of C. quinquedens using traditional cloning methods and their expression was quantified in the eyestalk ganglia at various ovarian stages. De novo transcriptome assembly of the eyestalk...
- Subject
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Brachyura/geneticsInvertebrate Hormones/geneticsNeuropeptides
- Access Rights
- Unrestricted access
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UMB Dataset
Identifying enhancer properties associated with genetic risk for complex traits using regulome-wide association studies
- Authors
- Alex M. CasellaCarlo ColantuoniSeth A. Ament
- Description
This study introduces a novel application of the MAGMA (Multi-marker Analysis of GenoMic Annotation) software tool that enables testing for associations between enhancer attributes and risk to determine the enhancer characteristics that are associated with risk for schizophrenia. The study uses the RWAS (Regulome Wide Association Study) framework to first collect enhancer annotations in a tissue...
- Subject
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Genome-Wide Association StudyMultifactorial Inheritance
- Access Rights
- Unrestricted access
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UMB Dataset
Culture Condition of Bone Marrow Stromal Cells Affects Quantity and Quality of the Extracellular Vesicles
- Authors
- Amanda L. ScheiberCierra A. ClarkTakashi KaitoMasahiro Iwamoto3 more author(s)...
- Description
Extracellular vehicles (EVs) released from bone marrow stromal cells (BMSCs) have been demonstrated to play an important role in their therapeutic actions for various diseases. This study establishes a scalable and reproducible EV manufacturing processes needed to develop successful implementation of EV therapy for patients. Using human BMSCs isolated from nine healthy donors, researchers examined...
- Subject
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Cell- and Tissue-Based Therapy/methods
- Access Rights
- Unrestricted access
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UMB Dataset
Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington’s Disease Mutations
- Authors
- Sonia MalaiyaMarcia Cortes-GutierrezBrian R. HerbSydney R. Coffey5 more author(s)...
- Description
The involvement of specific medium spiny neuro (MSN) subtype and of other striatal cell types remains poorly understood. To gain insight into cell type-specific disease processes, researchers studied the nuclear transcriptomes of 4524 cells from the striatum of a genetically precise knock-in mouse model of the Huntington's Disease (HD) mutation, HttQ175/1. Three 14-month-old and one 15-month-old male...
- Subject
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Sequence Analysis, RNA
- Timeframe
- 2020
- Access Rights
- Unrestricted access
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UMB Dataset
Genotyping Plasmodium falciparum gametocytes using amplicon deep sequencing
- Authors
- Jimmy VaretaNatalie A. HorstmanMatthew AdamsKarl B. Seydel4 more author(s)...
- Description
A data set of polymorphic regions of the P. falciparum genome was mined to identify a gametocyte genotyping marker. To assess marker resolution, the number of unique haplotypes in the marker region was estimated from 205 Malawian P. falciparum whole genome sequences. Specificity of the marker for detection of mature gametocytes was evaluated using reverse transcription-polymerase chain reaction of...
- Subject
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Plasmodium falciparum/genetics
- Access Rights
- Unrestricted access
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UMB Dataset
Staphylococcus aureus strain MRSA1, whole genome shotgun sequencing project
- Alternate Title(s)
- Examination of 388 Staphylococcus aureus Isolates from Intensive Care Unit Patients
- Authors
- Timileyin AdedrianStephanie HitchcockLyndsay M. O’HaraJane M. Michalski6 more author(s)...
- Description
The dataset contains data pertaining to the examination of draft genomes of 388 methicillin-resistant Staphylococcus aureus isolates obtained from intensive care unit patients at three geographically distributed hospitals. The purpose of the study was to determine genomic diversity associated with potential health care worker-associated transmission. Relevant statistics, including linked GenBank and...
- Subject
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Disease Transmission, InfectiousIntensive Care UnitsMethicillin-Resistant Staphylococcus aureusWhole Genome Sequencing
- Access Rights
- Unrestricted access
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UMB Dataset
Seasonal changes in the expression of insulinlike androgenic hormone (IAG) in the androgenic gland of the Jonah crab, Cancer borealis
- Authors
- Amanda LawrenceShadaesha GreenTao WangTsvetan Bachvaroff1 more author(s)...
- Description
This study aimed to identify the insulin-like androgenic gland factor (IAG) in adult male Jonah crabs as it plays an essential role in sexual maturity. The study also aimed to examine if seasonal changes influence IAG expression in males. The study used the androgenic gland transcriptome to test if eyestalk neuropeptides regulate IAG levels via an endocrine axis between the two endocrine tissues as...
- Subject
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BrachyuraSexual MaturationTranscriptome
- Access Rights
- Unrestricted access
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UMB Dataset
Strain-specific alterations in gut microbiome and host immune responses elicited by tolerogenic Bifidobacterium pseudolongum
- Authors
- Bing MaSamuel J. GavzyVikas SaxenaYang Song12 more author(s)...
- Description
To determine strain-specific driving mechanisms of B. pseudolongum UMB-MBP-01, researchers compared it to porcine tropic strain B. pseudolongum ATCC25526 using cell culture and in vivo experimentation and comparative genomic approaches. The data demonstrates that these two strains possess distinct genetic repertoires in carbohydrate assimilation, differential activation signatures and cytokine responses...
- Subject
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Immunity
- Access Rights
- Unrestricted access
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UMB Dataset
Small molecules inhibitors of the heterogeneous ribonuclear protein A18 (hnRNP A18): a regulator of protein translation and an immune checkpoint
- Authors
- Eduardo Solano-GonzalezKatherine M. CoburnWenbo YuGerald M. Wilson6 more author(s)...
- Description
Researchers utilized SILCS-based techniques to map the functional group requirements of hnRNP A18, aiming to create a pharmacophore for virtual screening. Data was obtained using the crystal structure of the hnRNP A18 RRM domain and various software tools. These simulations generated 3D functional group probability distributions of organic solutes, forming the basis for pharmacophore models. Virtual...
- Subject
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RNA-Binding Proteins / chemistryRNA-Binding Proteins/antagonists & inhibitors
- Access Rights
- Unrestricted access