UMB Data Catalog
A project of the Health Sciences and Human Services LibraryIdentifying enhancer properties associated with genetic risk for complex traits using regulome-wide association studies
UMB Dataset
UID: 185
- Description
- This study introduces a novel application of the MAGMA (Multi-marker Analysis of GenoMic Annotation) software tool that enables testing for associations between enhancer attributes and risk to determine the enhancer characteristics that are associated with risk for schizophrenia. The study uses the RWAS (Regulome Wide Association Study) framework to first collect enhancer annotations in a tissue relevant to the trait of interest, then identifies specific risk-associated enhancers by aggregating the effects of all SNPs (single nucleotide polymorphisms) that overlap the enhancer’s position in the genome, and finally, tests for associations of enhancer features with disease risk using a regression framework.
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Access via NeMO Archive
Enhancer annotation files
Access via GitHubCode
- Access Restrictions
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Unrestricted access
- Access Instructions
- All enhancer annotation files are available on the NeMO Archive. Code can be found on GitHub. Additional data can be found within the article's supplementary materials.
- Associated Publications
- Data Type
- Software Used
- Study Type
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Observational
- Dataset Format(s)
- Plain Text, TIFF, LOC
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