UMB Dataset
Culture Condition of Bone Marrow Stromal Cells Affects Quantity and Quality of the Extracellular Vesicles
UID: 210
- Description
- Extracellular vehicles (EVs) released from bone marrow stromal cells (BMSCs) have been demonstrated to play an important role in their therapeutic actions for various diseases. This study establishes a scalable and reproducible EV manufacturing processes needed to develop successful implementation of EV therapy for patients. Using human BMSCs isolated from nine healthy donors, researchers examined the effects of high-performance culture media that can rapidly expand BMSCs on EV production and quality in comparison with the conventional culture medium.
Access
- Restrictions
-
Unrestricted access
- Instructions
- The sequencing data underlying this article are available in the GEO.
Interventional
Benjamini–Hochberg method
unpaired two-tailed t-test
One-Way ANOVA
Two-Way ANOVA
Tukey's multiple comparison test
- Grant Support
-
2018-MSCRFD-4331/Maryland Stem Cell Research FundR21AR077654/NIAMSR01AR075733/NIAMS