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Results Found: 3
  • UMB Dataset

    The optic nerve lamina region is a neural progenitor cell niche

    Authors
    Steven L. Bernstein
    Yan Guo
    Rebecca Fawcett
    Candace Kerr
    3 more author(s)...
    Description

    Tissue from the optic nerve lamina region (ONLR), were dissected from both mice and humans. Immunohistochemistry (IHC) was then performed on tissue sections, and Ki67 mitosis assays assessed cell proliferation. Cell cultivation techniques isolated and cultured cells from ONLR and optic nerve tissues. Further experiments induced cell differentiation and neurosphere formation. Transgenic animal studies...

    Subject
    Optic Nerve
    Access Rights
    Unrestricted access
    Approval required
  • UMB Dataset

    Approaches to Potentiated Neuroprotective Treatment in the Rodent Model of Ischemic Optic Neuropathy

    Authors
    Zara Mehrabian
    Yan Guo
    Neil R. Miller
    Amanda D. Henderson
    2 more author(s)...
    Description

    Nonarthritic anterior ischemic optic neuropathy (NAION) commonly causes sudden optic nerve (ON)-related vision loss. The rodent NAION model (rAION) closely resembles NAION in presentation and physiological responses. Researchers hypothesized that blocking pro-inflammatory prostaglandin (PGE2) production by inhibiting monoacylglycerol lipase or cyclooxygenase activity and co-administering PGJ2 would...

    Subject
    Optic Nerve Diseases
    Timeframe
    2021
    Access Rights
    Unrestricted access
  • UMB Dataset

    Biomarkers of lesion severity in a rodent model of nonarthritic anterior ischemic optic neuropathy (rNAION)

    Authors
    Yan Guo
    Zara Mehrabian
    Mary A. Johnson
    Neil R. Miller
    3 more author(s)...
    Description

    The rodent model of nonarthritic anterior ischemic optic neuropathy (rNAION) is similar in many of its pathophysiological responses to clinical NAION. Like human NAION, there is significant variability in the severity of the lesion produced, and little is known of the parameters associated with rNAION induction severity or if pre- or early post-induction biomarkers can be identified that enable prediction...

    Subject
    Optic Nerve Diseases
    Access Rights
    Unrestricted access