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  • MR-Guided Transcranial Focused Ultrasound Safely Enhances Interstitial Disperson of Large Polymeric Nanoparticles in the Living Brain
    UMB Dataset

    Graeme F. Woodworth
    Victor Frenkel
    David S. Hersh
    Pavlos Anastasiadis
    7 more author(s)...

    This study tested the viability of using MRI-guided transcranial focused ultrasound (MRgFUS) to modify the interstitial space in the living brain. As a non-invasive technique, success in generating spatially controlled, non-destructive changes could lead to clinical applications such as enhancing delivery of therapeutics and altering fluid and pressure dynamics. The research involved the use of computer simulations for treatment planning and MRI acoustic radiation force impulse imaging for target validation. Additionally, Evans blue dye or nanoparticle probes were utilized to assess changes in the interstitium.This dataset includes a variety of histological, acoustic simulation, and electrophysiological images and tabular data of compressional acoustic properties of skull and brain tissue and physiochemical properties of nanoparticles.

    Magnetic Resonance Imaging, Interventional
    Ultrasonic Therapy
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  • Nanomagnetic-Mediated Drug Delivery for the Treatment of Dental Disease
    UMB Dataset

    Radi Masri

    This research tested the efficacy of utilizing nanoparticles, external magnetic forces, and dentinal tubules as conduits for delivering therapeutic agents to dental pulp. Moderate-size cavities were created in the dentin of rat mandibular molars and treated via the use of external magnetic forces to actively transport prednisolone-eluting magnetic nanoparticles to tooth pulp. Control groups included untreated teeth and teeth treated without magnetic pull. Expression of 4 cytokines were assessed at 2 weeks, 4 weeks, and 6 months. Additionally, the delivery system was investigated for use in actively guiding resin adhesives and the effect on shear bond strength on freshly extracted human molars. Dataset includes cytokine expression analysis and histological data.


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