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MR-Guided Transcranial Focused Ultrasound Safely Enhances Interstitial Disperson of Large Polymeric Nanoparticles in the Living Brain
UMB Dataset

UID: 61

Author(s): Graeme F. Woodworth*, Victor Frenkel*, David S. Hersh, Pavlos Anastasiadis, Ali Mohammadabadi, Ben A. Nguyen, Sijia Guo, Jeffrey Allan Winkles, Anthony J. Kim, Rao P. Gullapalli, Asaf Keller * Corresponding Author
Description
This study tested the viability of using MRI-guided transcranial focused ultrasound (MRgFUS) to modify the interstitial space in the living brain. As a non-invasive technique, success in generating spatially controlled, non-destructive changes could lead to clinical applications such as enhancing delivery of therapeutics and altering fluid and pressure dynamics. The research involved the use of computer simulations for treatment planning and MRI acoustic radiation force impulse imaging for target validation. Additionally, Evans blue dye or nanoparticle probes were utilized to assess changes in the interstitium.This dataset includes a variety of histological, acoustic simulation, and electrophysiological images and tabular data of compressional acoustic properties of skull and brain tissue and physiochemical properties of nanoparticles.
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All relevant data are within the paper and its Supporting Information files
Associated Publications
Equipment Used
Commercial MRgFUS System
Study Type
Empirical Research
Grant Support
1557922/National Science Foundation
Research Grant/Focused Ultrasound Foundation
Other Resources
S1 Figure (TIF)

Automated segmentation of locally delivered EBD

S2 Figure (TIF)

Volumetric reconstructions

S1 Checklist (PDF)

ARRIVE guidelines checklist