Description: This study tested the viability of using MRI-guided transcranial focused ultrasound (MRgFUS) to modify the interstitial space in the living brain. As a non-invasive technique, success in generating spatially controlled, non-destructive changes could lead to clinical applications such as enhancing delivery of therapeutics and altering fluid and pressure dynamics. The research involved the use of computer simulations for treatment planning and MRI acoustic radiation force impulse imaging for target validation. Additionally, Evans blue dye or nanoparticle probes were utilized to assess changes in the interstitium.This dataset includes a variety of histological, acoustic simulation, and electrophysiological images and tabular data of compressional acoustic properties of skull and brain tissue and physiochemical properties of nanoparticles.

Subject of Study

Subject Domain

Keywords

Restrictions: Unrestricted access
Instructions: All relevant data are within the paper and its Supporting Information files; Access via Article
Embedded tables, figures, graphs & images

Associated Publications

Equipment Used

Commercial MRgFUS System

Study Type

Empirical Research

Grant Support: K08NS09043/NIH

1557922/National Science Foundation

Research Grant/Focused Ultrasound Foundation
Other Resources: S1 Figure (TIF)
Automated segmentation of locally delivered EBD

S2 Figure (TIF)
Volumetric reconstructions

S1 Checklist (PDF)
ARRIVE guidelines checklist

MR-Guided Transcranial Focused Ultrasound Safely Enhances Interstitial Disperson of Large Polymeric Nanoparticles in the Living Brain