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  • Multi-center analysis of single-fraction versus hypofractionated stereotactic radiosurgery for the treatment of brain metastasis
    UMB Dataset

    Authors
    Mark V. Mishra
    Jill S. Remick
    Emily Kowalski
    Rahul Khairnar
    13 more author(s)...
    Description

    Stereotactic radiosurgery (SRS) is currently the standard radiation approach for treating brain metastases. This retrospective study compared two SRS methods, single fraction (SF-SRS) and hypo-fractionated (HS-SRS), for co-primary outcomes of local control and incidence of radiation necrosis. The review included 156 consecutive patients with a combined total of 335 metastatic brain lesions treated from 2013 to 2018 with SF-SRS (n = 222 lesions) or HF-SRS (n = 113 lesions). While dosing was standardized for the former it varied for the latter. Consequently, an analysis was conducted of a dose response using biological effective dose information (BED) as a surrogate measure for total dose. Study inclusion criteria were patient age greater than or equal to 18, a pathologically confirmed systemic malignancy, and an MRI confirming the presence of brain metastasis. Lesions without adequate follow up information or that were re-irradiated for local failure were excluded. Dataset includes patient demographics, individual tumor characteristics (clinical, radiographic, pathologic), treatment regimen, and univariate and multivariate analysis for local failure and radiation necrosis.

    Subject
    Brain
    Neoplasm Metastasis
    Radiosurgery
    Geographic Coverage
    Maryland
    Access Rights
    Approval required

  • MR-Guided Transcranial Focused Ultrasound Safely Enhances Interstitial Disperson of Large Polymeric Nanoparticles in the Living Brain
    UMB Dataset

    Authors
    Graeme F. Woodworth
    Victor Frenkel
    David S. Hersh
    Pavlos Anastasiadis
    7 more author(s)...
    Description

    This study tested the viability of using MRI-guided transcranial focused ultrasound (MRgFUS) to modify the interstitial space in the living brain. As a non-invasive technique, success in generating spatially controlled, non-destructive changes could lead to clinical applications such as enhancing delivery of therapeutics and altering fluid and pressure dynamics. The research involved the use of computer simulations for treatment planning and MRI acoustic radiation force impulse imaging for target validation. Additionally, Evans blue dye or nanoparticle probes were utilized to assess changes in the interstitium.This dataset includes a variety of histological, acoustic simulation, and electrophysiological images and tabular data of compressional acoustic properties of skull and brain tissue and physiochemical properties of nanoparticles.

    Subject
    Brain
    Magnetic Resonance Imaging, Interventional
    Ultrasonic Therapy
    Access Rights
    Unrestricted access

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