UMB Data Catalog
A project of the Health Sciences and Human Services LibraryMulti-center analysis of single-fraction versus hypofractionated stereotactic radiosurgery for the treatment of brain metastasis
UMB Dataset
UID: 110
- Description
- Stereotactic radiosurgery (SRS) is currently the standard radiation approach for treating brain metastases. This retrospective study compared two SRS methods, single fraction (SF-SRS) and hypo-fractionated (HS-SRS), for co-primary outcomes of local control and incidence of radiation necrosis. The review included 156 consecutive patients with a combined total of 335 metastatic brain lesions treated from 2013 to 2018 with SF-SRS (n = 222 lesions) or HF-SRS (n = 113 lesions). While dosing was standardized for the former it varied for the latter. Consequently, an analysis was conducted of a dose response using biological effective dose information (BED) as a surrogate measure for total dose. Study inclusion criteria were patient age greater than or equal to 18, a pathologically confirmed systemic malignancy, and an MRI confirming the presence of brain metastasis. Lesions without adequate follow up information or that were re-irradiated for local failure were excluded. Dataset includes patient demographics, individual tumor characteristics (clinical, radiographic, pathologic), treatment regimen, and univariate and multivariate analysis for local failure and radiation necrosis.
- Timeframe
- 2013 - 2018
Female
Male
- Access Restrictions
-
Approval required
- Access Instructions
- Please contact Dr. Mark Mishra
- Associated Publications
- Data Type
- Equipment Used
- Software Used
- Study Type
-
Observational
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