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Multi-center analysis of single-fraction versus hypofractionated stereotactic radiosurgery for the treatment of brain metastasis
UMB Dataset

UID: 110

Author(s): Mark V. Mishra*, Jill S. Remick, Emily Kowalski, Rahul Khairnar, Kai Sun, Emily Morse, Hua-Ren R. Cherng, Yannick Poirier, Narottam Lamichhane, Stewart J. Becker, Shifeng Chen, Akshar N. Patel, Young Kwok, Elizabeth Nichols, Pranshu Mohindra, Graeme F. Woodworth, William F. Regine * Corresponding Author
Stereotactic radiosurgery (SRS) is currently the standard radiation approach for treating brain metastases. This retrospective study compared two SRS methods, single fraction (SF-SRS) and hypo-fractionated (HS-SRS), for co-primary outcomes of local control and incidence of radiation necrosis. The review included 156 consecutive patients with a combined total of 335 metastatic brain lesions treated from 2013 to 2018 with SF-SRS (n = 222 lesions) or HF-SRS (n = 113 lesions). While dosing was standardized for the former it varied for the latter. Consequently, an analysis was conducted of a dose response using biological effective dose information (BED) as a surrogate measure for total dose. Study inclusion criteria were patient age greater than or equal to 18, a pathologically confirmed systemic malignancy, and an MRI confirming the presence of brain metastasis. Lesions without adequate follow up information or that were re-irradiated for local failure were excluded. Dataset includes patient demographics, individual tumor characteristics (clinical, radiographic, pathologic), treatment regimen, and univariate and multivariate analysis for local failure and radiation necrosis.
2013 - 2018
Subject of Study
Subject Domain
Subject Gender
Access Restrictions
Approval required
Access Instructions
Please contact Dr. Mark Mishra
Associated Publications
Data Type
Equipment Used
Gamma Knife
Varian Edge linear accelerator
Software Used
SAS 9.4
Study Type