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  • Strategies to Integrate Genomic Medicine into Clinical Care: Evidence from the IGNITE Network
    UMB Dataset

    Authors
    Nina R. Sperber
    Olivia M. Dong
    Megan C. Roberts
    Paul Dexter
    12 more author(s)...
    Description

    Clinical decision support (CDS) is a method to streamline the complexity of genomic medicine. Researchers conducted an in-depth evaluation of implementation strategies across a network focused on implementing genomic medicine, called Implementing Genomics In Practice, to gather data on common strategies for applying provider-based CDS interventions. The first phase used a web-based, self-administered, 15 minute structured survey derived from a typology of implementation strategies, the Expert Recommendations for Implementing Change (ERIC). The structured survey was used to gather information on implementation strategies used at sites. Follow-up interviews, guided by both implementation strategy reporting criteria and a planning framework, RE-AIM, obtained more detail about implementation strategies and desired outcomes.

    Subject
    Decision Support Systems, Clinical
    Geographic Coverage
    United States
    Timeframe
    2021
    Access Rights
    Unrestricted access

  • Qualitative study of comprehension of heritability in genomics studies among the Yoruba in Nigeria
    UMB Dataset

    Authors
    Clement A. Adebamowo
    Rasheed O. Taiwo
    John Ipadeola
    Temilola Yusuf
    3 more author(s)...
    Description

    To address concerns about comprehension and adequacy of informed consent, qualitative data was collected to examine whether there are linguistic and cultural concepts used to communicate heritability of characters, traits, and diseases in an indigenous African population. Researchers conducted focus group discussions among 115 participants and key informant interviews among 25 stakeholders and key opinion leaders among Yoruba living in Ibadan, Nigeria. The resulting dataset was contributed to the INDIGENE study which uses qualitative research methods to elicit these words and use them to design “enhanced informed consent” forms that are compared with standard informed consent in a randomized trial.

    Subject
    Informed Consent/ethics
    Geographic Coverage
    International
    Access Rights
    Unrestricted access

  • Strain-specific alterations in gut microbiome and host immune responses elicited by tolerogenic Bifidobacterium pseudolongum
    UMB Dataset

    Authors
    Bing Ma
    Samuel J. Gavzy
    Vikas Saxena
    Yang Song
    12 more author(s)...
    Description

    To determine strain-specific driving mechanisms of B. pseudolongum UMB-MBP-01, researchers compared it to porcine tropic strain B. pseudolongum ATCC25526 using cell culture and in vivo experimentation and comparative genomic approaches. The data demonstrates that these two strains possess distinct genetic repertoires in carbohydrate assimilation, differential activation signatures and cytokine responses signatures in innate immune cells, and differential effects on lymph node morphology with unique local and systemic leukocyte distribution.

    Subject
    Immunity
    Access Rights
    Unrestricted access

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