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UMB Dataset
Small molecules inhibitors of the heterogeneous ribonuclear protein A18 (hnRNP A18): a regulator of protein translation and an immune checkpoint
- Authors
- Eduardo Solano-GonzalezKatherine M. CoburnWenbo YuGerald M. Wilson6 more author(s)...
- Description
Researchers utilized SILCS-based techniques to map the functional group requirements of hnRNP A18, aiming to create a pharmacophore for virtual screening. Data was obtained using the crystal structure of the hnRNP A18 RRM domain and various software tools. These simulations generated 3D functional group probability distributions of organic solutes, forming the basis for pharmacophore models. Virtual...
- Subject
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RNA-Binding Proteins / chemistryRNA-Binding Proteins/antagonists & inhibitors
- Access Rights
- Unrestricted access
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SEER-Medicare Linked Database
- Alternate Title(s)
- Surveillance, Epidemiology and End Results-Medicare Linked Database
- Description
This series of files links two large population-based sources providing detailed data about Medicare beneficiaries with cancer. The SEER (Surveillance, Epidemiology, and End Results) program consists of clinical, demographic, and cause of death information collected from tumor registries beginning in January 1, 1973. The Medicare contribution includes all claims for covered health care services from...
- Subject
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CancerPopulation CharacteristicsPopulation Surveillance
- Access Rights
- Approval requiredRegistration required
- Local Experts
- Arif Hussain
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UMB Dataset
Sleep, circadian rhythms and fatigue in children with CNS tumors hospitalized for high dose chemotherapy
- Authors
- Valerie E. RogersBelinda Mandrell
- Description
This study tested a sleep promotion intervention (randomized controlled trial) in children with recently diagnosed central nervous system tumors admitted to the hospital for high dose chemotherapy in preparation for autologous stem cell rescue. We hypothesized that disturbed sleep of hospitalized pediatric oncology patients would be reduced by altering the hospital sleep environment. Therefore, a randomized,...
- Subject
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Central Nervous System/CancerSleep Wake Disorders
- Access Rights
- Unrestricted access
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UMB Dataset
Circadian Rest-Activity Rhythms in Children with Leukemia on Dexamethasone
- Authors
- Valerie E. RogersBelinda Mandrell
- Description
This study measured circadian activity rhythms (CAR) and fatigue in children and adolescents with acute lymphoblastic leukemia on maintenance chemotherapy during the 5 days prior to a pulse of dexamethasone and the 5 days after the start of dexamethasone. CAR was measured via an actigraph worn continuously for 10 days. Fatigue was measured at 4 time points. The fatigue measures used for this study...
- Subject
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Circadian RhythmDexamethasoneLeukemia
- Access Rights
- Unrestricted access
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UMB Dataset
Circadian rhythms, fatigue and bright light therapy in adolescent cancer survivors
- Authors
- Valerie E. Rogers
- Description
This 2-phase study explored the differences in sleep and circadian activity rhythms between adolescents who were within 5 years of completing treatment for any type of cancer and healthy, age-matched controls; and trialed a morning bright light therapy intervention to gather preliminary evidence of its safety, feasibility and outcomes.
- Subject
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Cancer SurvivorsSleep Wake Disorders
- Access Rights
- Registration required