UMB Data Catalog

A project of the Health Sciences and Human Services Library
of 1 Next >
Results Found: 5
  • UMB Dataset

    Small molecules inhibitors of the heterogeneous ribonuclear protein A18 (hnRNP A18): a regulator of protein translation and an immune checkpoint

    Authors
    Eduardo Solano-Gonzalez
    Katherine M. Coburn
    Wenbo Yu
    Gerald M. Wilson
    6 more author(s)...
    Description

    Researchers utilized SILCS-based techniques to map the functional group requirements of hnRNP A18, aiming to create a pharmacophore for virtual screening. Data was obtained using the crystal structure of the hnRNP A18 RRM domain and various software tools. These simulations generated 3D functional group probability distributions of organic solutes, forming the basis for pharmacophore models. Virtual...

    Subject
    RNA-Binding Proteins / chemistry
    RNA-Binding Proteins/antagonists & inhibitors
    Access Rights
    Unrestricted access
  • SEER-Medicare Linked Database

    Alternate Title(s)
    Surveillance, Epidemiology and End Results-Medicare Linked Database
    Description

    This series of files links two large population-based sources providing detailed data about Medicare beneficiaries with cancer. The SEER (Surveillance, Epidemiology, and End Results) program consists of clinical, demographic, and cause of death information collected from tumor registries beginning in January 1, 1973. The Medicare contribution includes all claims for covered health care services from...

    Subject
    Cancer
    Population Characteristics
    Population Surveillance
    Access Rights
    Approval required
    Registration required
    Local Experts
    Arif Hussain
  • UMB Dataset

    Sleep, circadian rhythms and fatigue in children with CNS tumors hospitalized for high dose chemotherapy

    Authors
    Valerie E. Rogers
    Belinda Mandrell
    Description

    This study tested a sleep promotion intervention (randomized controlled trial) in children with recently diagnosed central nervous system tumors admitted to the hospital for high dose chemotherapy in preparation for autologous stem cell rescue. We hypothesized that disturbed sleep of hospitalized pediatric oncology patients would be reduced by altering the hospital sleep environment. Therefore, a randomized,...

    Subject
    Central Nervous System/Cancer
    Sleep Wake Disorders
    Access Rights
    Unrestricted access
  • UMB Dataset

    Circadian Rest-Activity Rhythms in Children with Leukemia on Dexamethasone

    Authors
    Valerie E. Rogers
    Belinda Mandrell
    Description

    This study measured circadian activity rhythms (CAR) and fatigue in children and adolescents with acute lymphoblastic leukemia on maintenance chemotherapy during the 5 days prior to a pulse of dexamethasone and the 5 days after the start of dexamethasone. CAR was measured via an actigraph worn continuously for 10 days. Fatigue was measured at 4 time points. The fatigue measures used for this study...

    Subject
    Circadian Rhythm
    Dexamethasone
    Leukemia
    Access Rights
    Unrestricted access
  • UMB Dataset

    Circadian rhythms, fatigue and bright light therapy in adolescent cancer survivors

    Authors
    Valerie E. Rogers
    Description

    This 2-phase study explored the differences in sleep and circadian activity rhythms between adolescents who were within 5 years of completing treatment for any type of cancer and healthy, age-matched controls; and trialed a morning bright light therapy intervention to gather preliminary evidence of its safety, feasibility and outcomes.

    Subject
    Cancer Survivors
    Sleep Wake Disorders
    Access Rights
    Registration required