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Results Found: 3

  • Strain-specific alterations in gut microbiome and host immune responses elicited by tolerogenic Bifidobacterium pseudolongum
    UMB Dataset

    Authors
    Bing Ma
    Samuel J. Gavzy
    Vikas Saxena
    Yang Song
    12 more author(s)...
    Description

    To determine strain-specific driving mechanisms of B. pseudolongum UMB-MBP-01, researchers compared it to porcine tropic strain B. pseudolongum ATCC25526 using cell culture and in vivo experimentation and comparative genomic approaches. The data demonstrates that these two strains possess distinct genetic repertoires in carbohydrate assimilation, differential activation signatures and cytokine responses signatures in innate immune cells, and differential effects on lymph node morphology with unique local and systemic leukocyte distribution.

    Subject
    Immunity
    Access Rights
    Unrestricted access

  • Methylsulfonylmethane Increases the Alveolar Bone Density of Mandibles in Aging Female Mice
    UMB Dataset

    Authors
    Hanan Aljohani
    Linda T. Senbanjo
    Mohammed Al Qranei
    Joseph P. Stains
    1 more author(s)...
    Description

    Thirty-six-week-old again female C5BL/6 mice were injected with MSM for thirteen weeks. Researchers examined the effects of MSM on bone density and development using micro-computed tomographic images, serum analyses, and immunohistochemical analyses.

    Subject
    Osteogenesis
    Access Rights
    Unrestricted access

  • Comparison of In Vivo Expression Levels of IL-4 and IL-4d2 in Mouse Lung Tissue
    UMB Dataset

    Alternate Title(s)
    Comparison of In Vivo Expression Levels of IL-4 and IL-4 delta2 in Mouse Lung Tissue
    Authors
    Sergei P. Atamas
    Irina G. Luzina
    Virginia Lockatell
    Nevins W. Todd
    3 more author(s)...
    Description

    The primary goal of this project was to compare in vivo gene expression levels of the cytokine, IL-4, and its natural splice variant, IL-4δ2, in the lungs of mice. Intratracheal replication-deficient adenovirus-mediated gene delivery of mouse IL-4 or IL-4δ2 was utilized to create three mice overexpressing IL-4 and three overexpressing IL-4δ2 in their lungs. An additional three mice were similarly infected with control AdV-NULL virus not encoding a cytokine. 14 days postinfection, lung tissue was homogenized, total RNA extracted, and results analyzed. The data demonstrate that IL-4 and its splice variant differentially affect global gene expression which has implications for the use of targeted therapy for various diseases. The dataset consists of 9 microarray data tables corresponding to each of the samples. Additionally, a supplementary TAR file of the raw data is also available to download.

    Subject
    Gene Expression Profiling
    Microarray Analysis
    Timeframe
    2010
    Access Rights
    Unrestricted access

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