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  • Biomarkers of lesion severity in a rodent model of nonarthritic anterior ischemic optic neuropathy (rNAION)
    UMB Dataset

    Authors
    Yan Guo
    Zara Mehrabian
    Mary A. Johnson
    Neil R. Miller
    3 more author(s)...
    Description

    The rodent model of nonarthritic anterior ischemic optic neuropathy (rNAION) is similar in many of its pathophysiological responses to clinical NAION. Like human NAION, there is significant variability in the severity of the lesion produced, and little is known of the parameters associated with rNAION induction severity or if pre- or early post-induction biomarkers can be identified that enable prediction of lesion severity and ultimate loss of retinal ganglion cells (RGCs). Adult male Sprague-Dawley outbred rats were evaluated for various parameters including physiological characteristics (heart rate, respiratory rate, temperature, hematocrit [Hct]), optic nerve head (ONH) appearance, pre- and post-induction mean diameter, and intravenous fluorescein and indocyanine green angiographic patterns of vascular leakage at 5 hours post-induction, performed using a spectral domain-optical coherence tomography (SD-OCT) instrument.

    Subject
    Optic Nerve Diseases
    Access Rights
    Unrestricted access

  • GISAID

    Alternate Title(s)
    Global Initiative on Sharing All Influenza Data
    Description

    "The GISAID Initiative promotes the rapid sharing of data from all influenza viruses and the coronavirus causing COVID-19. This includes genetic sequence and related clinical and epidemiological data associated with human viruses, and geographical as well as species-specific data associated with avian and other animal viruses, to help researchers understand how viruses evolve and spread during epidemics and pandemics. GISAID does so by overcoming disincentive hurdles and restrictions, which discourage or prevented sharing of virological data prior to formal publication." (From "Mission")

    Subject
    COVID-19
    Influenza in Birds
    Influenza, Human
    Geographic Coverage
    International
    Access Rights
    Unrestricted access
    Local Experts
    Davide Zella
    Francesca Benedetti
    Robert C. Gallo

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