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  • UMB Dataset

    Prion Replication Environment Defines the Fate of Prion Strain Adaptation

    Authors
    Ilia V. Baskakov
    Elizaveta Katorcha
    Nuria Gonzalez-Montalban
    Natallia Makarava
    1 more author(s)...
    Description

    The research associated with this dataset explored cross-species prion transmission and the impact of cofactor environment on strain adaptation. Utilizing Protein Misfolding Cyclic Amplification with beads (PMCAb), hamster strain 263K was propagated under normal or RNA-depleted conditions first in mouse and then hamster substrates. A variety of readaptation experiments were conducted including brain...

    Subject
    Prion Diseases
    Zoonoses
    Access Rights
    Unrestricted access