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  • Biomarkers of Airway Inflammation and Asthma Control in Children with Comorbid Sleep-Disordered Breathing
    UMB Dataset

    Authors
    Valerie E. Rogers
    Mary E. Bollinger
    Mohan E. Tulapurkar
    Shijun Zhu
    3 more author(s)...
    Description

    A bi‐directional relationship exists between asthma and obstructive sleep apnea (OSA) in which presence of one is associated with increased prevalence and severity of the other. This study was undertaken to determine if OSA accounted for differences in airway and systemic inflammation in asthmatic children and if inflammation was associated with asthma control. 27 non-obese children aged 4-12 years with persistent asthma, with or without OSA, were recruited for the research. Asthma control was measured with the Childhood Asthma Control Test. Participants underwent polysomnography and blood sampling, and those with OSA also underwent clinically indicated adenotonsillectomy. Tonsils and sera were analyzed for 11 cytokines. The dataset includes demographic data, health history, spirometry/polysomnographic measures, and immunoassay values.

    Subject
    Asthma
    Inflammation
    Sleep Wake Disorders
    Access Rights
    Unrestricted access

  • Polysomnographic Characteristics of a Referred Sample of Children with Sickle Cell Disease
    UMB Dataset

    Authors
    Valerie E. Rogers
    Daniel S. Lewin
    Glenna B. Winnie
    Jeanne Geiger-Brown
    Description

    This was a retrospective medical record review of 55 consecutive children aged 2-18 years with sickle cell disease (SCD) (hemoglobin [Hb] SS and Hb SC genotypes) undergoing polysomnography for evaluation of sleep disordered breathing. Polysomnography values were compared between SCD genotypes, 4 age groups, and adenotonsillectomy status using descriptive and nonparametric statistics. Medical record data were collected for 12 months pre-polysomnography and 12 months post-polysomnography/adenotonsillectomy. This dataset includes demographic data, SCD type, polysomnographic values, and clinical measures.

    Subject
    Anemia, Sickle Cell
    Sleep Wake Disorders
    Access Rights
    Unrestricted access

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