UMB Data Catalog
A project of the Health Sciences and Human Services Library-
Differential nanoscale organization of excitatory synapses onto excitatory vs. inhibitory neurons
UMB Dataset- Authors
- Poorna A. DharmasriAaron D. LevyThomas A. Blanpied
- Description
Primary hippocampal neuron cultures obtained from Sprague-Dawley rat embryos were infected with lentivirus expressing EGFP. Immunostaining with specific antibodies was performed on fixed neurons. Confocal and DNA-PAINT microscopy were used for imaging, and custom analysis methods were applied to analyze the acquired images. Statistical analyses were conducted using GraphPad PRISM.
- Subject
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Disks Large Homolog 4 Protein/metabolismInterneurons/physiology
- Access Rights
- Unrestricted access
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Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington’s Disease Mutations
UMB Dataset- Authors
- Sonia MalaiyaMarcia Cortes-GutierrezBrian R. HerbSydney R. Coffey5 more author(s)...
- Description
The involvement of specific medium spiny neuro (MSN) subtype and of other striatal cell types remains poorly understood. To gain insight into cell type-specific disease processes, researchers studied the nuclear transcriptomes of 4524 cells from the striatum of a genetically precise knock-in mouse model of the Huntington's Disease (HD) mutation, HttQ175/1. Three 14-month-old and one 15-month-old male mice were used to generate the primary dataset.
- Subject
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Sequence Analysis, RNA
- Geographic Coverage
- International
- Timeframe
- 2020
- Access Rights
- Unrestricted access