UMB Data Catalog

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  • UMB Dataset

    Comparison of In Vivo Expression Levels of IL-4 and IL-4d2 in Mouse Lung Tissue

    Alternate Title(s)
    Comparison of In Vivo Expression Levels of IL-4 and IL-4 delta2 in Mouse Lung Tissue
    Authors
    Sergei P. Atamas
    Irina G. Luzina
    Virginia Lockatell
    Nevins W. Todd
    3 more author(s)...
    Description

    The primary goal of this project was to compare in vivo gene expression levels of the cytokine, IL-4, and its natural splice variant, IL-4δ2, in the lungs of mice. Intratracheal replication-deficient adenovirus-mediated gene delivery of mouse IL-4 or IL-4δ2 was utilized to create three mice overexpressing IL-4 and three overexpressing IL-4δ2 in their lungs. An additional three mice were similarly infected...

    Subject
    Gene Expression Profiling
    Microarray Analysis
    Timeframe
    2010
    Access Rights
    Unrestricted access
  • UMB Dataset

    mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant

    Authors
    Etsuro Nanishi
    Marisa E. McGrath
    Timothy R. O’Meara
    Soumik Barman
    17 more author(s)...
    Description

    This study investigates multiple vaccine strategies to enhance immunogenicity and protection against SARS-CoV-2 in aged mice. The study aims to determine the effect of a booster dose, with an emphasis on older age. Female three and eleven-month-old BALB/c mice were studied over the course of 38 weeks. Mice received BNT162b2 SARS-CoV-2 spike mRNA vaccine series, primary vaccination series, and mock...

    Subject
    COVID-19/prevention & control
    Viral Vaccines/genetics
    Access Rights
    Unrestricted access
    Local Experts
    Matthew B. Frieman