UMB Data Catalog

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Results Found: 2
  • UMB Dataset

    Transcriptomic comparisons of macroscopically normal-appearing and scarred lung tissues in idiopathic pulmonary fibrosis

    Authors
    Sergei P. Atamas
    Description

    Idiopathic pulmonary fibrosis (IPF) produces scarring in the peripheral and basilar regions of the lung with macroscopically normal-appearing tissue in the central and apical areas. This study involved comparing transcriptomic profiles of the latter with transcriptomes of scarred IPF and healthy control lung tissues. The primary goal of the research was to elucidate the pathobiology of the disease...

    Subject
    Gene Expression Profiling
    Sequence Analysis
    Access Rights
    Unrestricted access
  • UMB Dataset

    Comparison of In Vivo Expression Levels of IL-4 and IL-4d2 in Mouse Lung Tissue

    Alternate Title(s)
    Comparison of In Vivo Expression Levels of IL-4 and IL-4 delta2 in Mouse Lung Tissue
    Authors
    Sergei P. Atamas
    Irina G. Luzina
    Virginia Lockatell
    Nevins W. Todd
    3 more author(s)...
    Description

    The primary goal of this project was to compare in vivo gene expression levels of the cytokine, IL-4, and its natural splice variant, IL-4δ2, in the lungs of mice. Intratracheal replication-deficient adenovirus-mediated gene delivery of mouse IL-4 or IL-4δ2 was utilized to create three mice overexpressing IL-4 and three overexpressing IL-4δ2 in their lungs. An additional three mice were similarly infected...

    Subject
    Gene Expression Profiling
    Microarray Analysis
    Timeframe
    2010
    Access Rights
    Unrestricted access