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Transcriptomic comparisons of macroscopically normal-appearing and scarred lung tissues in idiopathic pulmonary fibrosis
UMB Dataset

UID: 12

Author(s): Sergei P. Atamas* * Corresponding Author
Description
Idiopathic pulmonary fibrosis (IPF) produces scarring in the peripheral and basilar regions of the lung with macroscopically normal-appearing tissue in the central and apical areas. This study involved comparing transcriptomic profiles of the latter with transcriptomes of scarred IPF and healthy control lung tissues. The primary goal of the research was to elucidate the pathobiology of the disease in its earliest stages. Tissue samples were taken from lung explants of 3 IPF patients and healthy lung tissue from 3 transplant donors. Dataset includes 10 sequence reads from macroscopically normal-appearing areas and 8 from scarred regions from IPF lungs, and an additional 8 from the normal control tissue for a total of 26 samples. 1 supplementary PDF and 7 supplementary datasets in Excel are available at: http://dx.doi.org/10.1016/j.cellimm.2018.01.002
Timeframe
2016 - 2017
Subject of Study
Subject Domain
Population Age
Adult (19 years to 64 years)
Senior (65 years to 79 years)
Subject Gender
Male
Keywords
Access Restrictions
Free to All
Access Instructions
Available from the NCBI GEO site
Associated Publications
Data Type
Equipment Used
Illumina HiSeq 2500
Software Used
BioVenn
DESeq2
GOrilla
HTSeq
Morpheus
STAR
Study Type
Empirical Research
Dataset Format(s)
Compressed FASTQ-SRA
Dataset Size
74 GB
Grant Support
I01CX000101/Veterans Administration Merit Award
I01BX002499/Veterans Administration Merit Award
Other Resources
Supplementary Material

Patient demographics and 7 supplementary datasets