UMB Data Catalog
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IFNa induces CCR5 in CD4+ T cells of HIV patients causing pathogenic elevation
UMB Dataset- Authors
- Hélène Le BuanecValérie SchiavonMarine MerandetAlexandre How-Kit11 more author(s)...
- Description
This study analyzed samples from 73 healthy donors and 81 individuals with HIV, divided into Natural Viral Suppressors (NVS), untreated non-EC patients (UP), and treated patients (TP). Samples were collected from various sources and subjected to serological, phenotypic, and virological assessments. Peripheral blood mononuclear cells (PBMCs) were isolated, CD4+T cells were stimulated, and flow cytometry was used to measure CCR5 and CXCR4 expression. Viral stocks were prepared from infectious molecular clones (IMCs), and virus growth kinetics were assessed. Immunophenotypic studies, cytokine quantification, and gene expression analyses were conducted.
- Subject
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HIV Infections/therapy
- Geographic Coverage
- Global
- Access Rights
- Unrestricted access