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  • Biomarkers of Airway Inflammation and Asthma Control in Children with Comorbid Sleep-Disordered Breathing
    UMB Dataset

    Authors
    Valerie E. Rogers
    Mary E. Bollinger
    Mohan E. Tulapurkar
    Shijun Zhu
    3 more author(s)...
    Description

    A bi‐directional relationship exists between asthma and obstructive sleep apnea (OSA) in which presence of one is associated with increased prevalence and severity of the other. This study was undertaken to determine if OSA accounted for differences in airway and systemic inflammation in asthmatic children and if inflammation was associated with asthma control. 27 non-obese children aged 4-12 years with persistent asthma, with or without OSA, were recruited for the research. Asthma control was measured with the Childhood Asthma Control Test. Participants underwent polysomnography and blood sampling, and those with OSA also underwent clinically indicated adenotonsillectomy. Tonsils and sera were analyzed for 11 cytokines. The dataset includes demographic data, health history, spirometry/polysomnographic measures, and immunoassay values.

    Subject
    Asthma
    Inflammation
    Sleep Wake Disorders
    Access Rights
    Unrestricted access

  • Post-transplant substance use, services use and psychosocial functioning among liver transplant recipients with a history of alcohol dependence
    UMB Dataset

    Authors
    Paul Sacco
    Description

    This data set consists of the results of a survey developed to examine substance use, psychosocial, and mental health variables in a sample of patients who received a liver transplant and were diagnosed with an alcohol-related liver disease. Participants were asked about their quantity, duration and frequency of alcohol and substance use prior to and following liver transplant. The Alcohol Use Disorders Identification Test (AUDIT), a 10-item measure for at risk drinking, assessed current alcohol consumption for participants who reported any past-year alcohol consumption. The Fagerstrom test assessed nicotine dependence using a six-item measure of nicotine dependence. The Patient Health Questionnaire (PHQ-9)(14) screened for depression symptomatology, and the Generalized Anxiety Disorder (GAD-7), a seven-item measure that assesses symptoms of worry and anxiety over the past two weeks (15) was used to screen for anxiety symptoms. The Interpersonal Support Evaluation List (ISEL-12) was used as a measure of social support. Other survey items included questions on demographic variables (i.e., marital status, employment, residency, history of incarceration) as well as substance use and mental health service utilization. Age, race/ethnicity, Model for End-Stage Liver Disease (MELD) score, insurance status, and transplant wait list time were extracted from patient medical records. A total of 67 individuals were surveyed.

    Subject
    Liver Transplant/psychology
    Geographic Coverage
    United States
    Access Rights
    Approval required

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