UMB Data Catalog
A project of the Health Sciences and Human Services Library-
Prion Replication Environment Defines the Fate of Prion Strain Adaptation
UMB Dataset- Authors
- Ilia V. BaskakovElizaveta KatorchaNuria Gonzalez-MontalbanNatallia Makarava1 more author(s)...
- Description
The research associated with this dataset explored cross-species prion transmission and the impact of cofactor environment on strain adaptation. Utilizing Protein Misfolding Cyclic Amplification with beads (PMCAb), hamster strain 263K was propagated under normal or RNA-depleted conditions first in mouse and then hamster substrates. A variety of readaptation experiments were conducted including brain analysis of hamsters inoculated with different PMCAb-derived material. Dataset includes Western blot and comparative histopathological brain images.
- Subject
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Prion DiseasesZoonoses
- Access Rights
- Unrestricted access