Human Disease Ontology (DO) Project release files. The DO project actively collaborates with biomedical and clinical researchers and data repositories to coordinate a standardized classification of human disease. The DO's GitHub repository includes the monthly releases (https://tinyurl.com/DiseaseOntologyReleases), of OWL, OBO, JSON and XML formatted files along with DO subsets (ontology slims) for the Alliance of Genome Resouces, FlyBase, Mouse Genome Informatics Database, the Immune Epitope Database, DO_Cancer_slim (for cancer variant resources), and zoonotic infectious diseases.The DO SPARQL GitHub directory provides a suite (https://tinyurl.com/DiseaseOntologySrcSparql) of data reporting and QC queries for the community to explore DO's data. File formats include OWL, OBO, JSON, and XML. User requests for disease term review or inclusion of new disease terms may be submitted via the DO GitHub tracker: https://github.com/DiseaseOntology/HumanDiseaseOntology/issues.