This study was undertaken to investigate the correlation between cervicovaginal microbiota, immunological factors, and race and the risk of premature birth. From a cohort of 2000 women with singleton pregnancies, 539 participated in the research with 432 delivering full term and 107 experiencing spontaneous preterm delivery. The racial breakdown consisted of 402 African American, 115 White, and 22 Other. Cervicovaginal samples and anthropomorphic measurements were collected during 3 visits: between 16-20, 20-24, and 24-28 weeks of gestation. The microbiota was characterized, immunological profiles were established, and the results evaluated according to race and delivery outcome. Data includes demographic, phenotype, clinical measures, statistical and metagenomic.

The Multi-Ethnic Study of Atherosclerosis (MESA) was designed to determine the characteristics of subclinical cardiovascular disease (CVD) and identify the risk factors associated with disease progression. Sponsored by the NIH’s National Heart Lung and Blood Institute, the research has been conducted by six university clinics located throughout the United States. Over 6,000 men and women aged 45 to 84 years were recruited for the first exam which took place over two years, from 2000 to 2002. Subsequently, participants have been contacted every 9-12 months to assess clinical morbidity and mortality with the sixth 2-year exam period ending in June 2018. The ethnic breakdown of the original cohort was: 38% white, 28% African-American, 22% Hispanic, and 12% Asian, predominantly of Chinese descent. The dataset includes demographic, medical history, lifestyle and psychosocial factors, clinical, laboratory values, genetic, and diagnostic imaging results.

This dataset is the result of a multi-center, 7 year prospective investigation into the biopsychosocial, environmental, and genetic risk factors associated with the onset and persistence of temporomandibular disorders (TMD). The OPPERA project consisted of 4 observational studies: a prospective cohort study of first-onset TMD, a baseline case-control study of chronic TMD, a matched case-control study of incident TMD, and a prospective case-cohort study of the course of TMD. Over 3,000 volunteers between the ages of 18-44 participated in the research. The data collected includes sociodemographic, psychosocial, clinical, physiological, and genetic (including biological pathways of genetic variants).

Diabetes, hypertension, and hypercholesterolemia are three of the major risk factors for the development of cardiovascular disease (CVD), a leading cause of death in the United States. The burden of these disorders is not uniform across the country primarily due to socioeconomic status, cultural practices, and lifestyle. To evaluate the effect of these disparities, this study compared the prevalence of the 3 conditions in a subpopulation in the US with that of the general population. The Old Order Amish (OOA) community located in rural Pennsylvania is characterized by distinctive sociocultural practices that include a very cohesive social structure and limited use of modern technologies and medication. A total of 5377 OOA individuals took part in a community-wide survey which included a physical exam and fasting blood draw. The prevalence of the 3 risk factors in the Amish was then compared to the European Caucasian subsample of the 2013–2014 US National Health and Nutrition Examination Survey (NHANES). This dataset includes demographics, physical examination values, medication history, clinical measures associated blood pressure, cholesterol, and glucose, and statistical assessment and comparison data.