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Cervicovaginal Microbiota and Local Immune Response Modulate the Risk of Spontaneous Preterm Delivery
UMB Dataset

UID: 59

Author(s): Jacques Ravel*, Michal A. Elovitz, Pawel Gajer, Valerie Ris, Amy G. Brown, Michael S. Humphrys, Johanna B. Holm * Corresponding Author
Description
This study was undertaken to investigate the correlation between cervicovaginal microbiota, immunological factors, and race and the risk of premature birth. From a cohort of 2000 women with singleton pregnancies, 539 participated in the research with 432 delivering full term and 107 experiencing spontaneous preterm delivery. The racial breakdown consisted of 402 African American, 115 White, and 22 Other. Cervicovaginal samples and anthropomorphic measurements were collected during 3 visits: between 16-20, 20-24, and 24-28 weeks of gestation. The microbiota was characterized, immunological profiles were established, and the results evaluated according to race and delivery outcome. Data includes demographic, phenotype, clinical measures, statistical and metagenomic.
Timeframe
2013 - 2017
Geographic Coverage
Maryland
Pennsylvania
Subject of Study
Subject Domain
Population Age
Adult (19 years to 64 years)
Subject Gender
Female
Keywords
Access via NCBI Genotypes and Phenotypes (dbGaP) Database

Sequence data and associated samples and subjects' metadata

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Access Instructions
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Associated Publications
Data Type
Equipment Used
Illumina HiSeq 2500 System
Study Type
Observational
Grant Support
Other Resources
Code

Analysis scripts