UMB Data Catalog

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Results Found: 4
  • UMB Dataset

    Comparison of In Vivo Expression Levels of IL-4 and IL-4d2 in Mouse Lung Tissue

    Alternate Title(s)
    Comparison of In Vivo Expression Levels of IL-4 and IL-4 delta2 in Mouse Lung Tissue
    Authors
    Sergei P. Atamas
    Irina G. Luzina
    Virginia Lockatell
    Nevins W. Todd
    3 more author(s)...
    Description

    The primary goal of this project was to compare in vivo gene expression levels of the cytokine, IL-4, and its natural splice variant, IL-4δ2, in the lungs of mice. Intratracheal replication-deficient adenovirus-mediated gene delivery of mouse IL-4 or IL-4δ2 was utilized to create three mice overexpressing IL-4 and three overexpressing IL-4δ2 in their lungs. An additional three mice were similarly infected...

    Subject
    Gene Expression Profiling
    Microarray Analysis
    Timeframe
    2010
    Access Rights
    Unrestricted access
  • UMB Dataset

    Transcriptomic comparisons of macroscopically normal-appearing and scarred lung tissues in idiopathic pulmonary fibrosis

    Authors
    Sergei P. Atamas
    Description

    Idiopathic pulmonary fibrosis (IPF) produces scarring in the peripheral and basilar regions of the lung with macroscopically normal-appearing tissue in the central and apical areas. This study involved comparing transcriptomic profiles of the latter with transcriptomes of scarred IPF and healthy control lung tissues. The primary goal of the research was to elucidate the pathobiology of the disease...

    Subject
    Gene Expression Profiling
    Sequence Analysis
    Access Rights
    Unrestricted access
  • UMB Dataset

    Plasmodium vivax Transcriptomes Reveal Stage-specific Chloroquine Response and Differential Regulation of Male and Female Gametocytes

    Authors
    Adam Kim
    Jean Popovici
    Didier Menard
    David Serre
    Description

    Plasmodium vivax is the most widespread human malaria parasite. However, its biology is little understood for a number of reasons, not the least of which is the inability to continuously propagate it in vitro. Utilizing samples of whole blood taken from 26 Cambodian patients who were determined to be solely infected with the parasite, this research investigated three aspects of P. vivax activity: 1)...

    Subject
    Gene Expression Profiling
    Plasmodium vivax
    Access Rights
    Unrestricted access
  • UMB Dataset

    Analysis of Rickettsia typhi-Infected and Uninfected Cat Flea (Ctenocephalides felis) Midgut cDNA Libraries: Deciphering Molecular Pathways Involved in Host Response to R. typhi Infection

    Authors
    Abdu F. Azad
    Sheila M. Dreher-Lesnick
    Shane M. Ceraul
    Sky C. Lesnick
    4 more author(s)...
    Description

    Murine typhus is a febrile disease caused by the bacterium, Rickettsia typhi (R. typhi), and transmitted via infected fleas. This study investigated midgut responses of infected versus uninfected cat fleas (Ctenocephalides felis) by constructing cDNA libraries and examining transcript levels. Select C. felis serine proteases, GTPases and defense response genes were compared to identify differences...

    Subject
    Ctenocephalides
    Gene Expression Profiling
    Rickettsia typhi
    Transcription, Genetic
    Timeframe
    2009
    Access Rights
    Unrestricted access