UMB Data Catalog

A project of the Health Sciences and Human Services Library
Find Datasets from
UMB Researchers
Include your dataset
of 1 Next >
Results Found: 3

  • Serious adverse events of special interest following mRNA COVID-19 vaccination in randomized trials in adults
    UMB Dataset

    Authors
    Joseph Fraiman
    Juan Erviti
    Mark Jones
    Sander Greenland
    3 more author(s)...
    Description

    An adapted version of the Brighton Collaboration priority list was used to evaluate serious adverse events (SAE) of special interest observed in mRNA Covid-19 vaccine trials. In December of 2020, reviewers searched journal publications and trial data on the FDA’s and Health Canada’s websites to locate SAE results tables for these trials. For each trial, blinded SAE tables were prepared. Using these blinded SAE tables, two clinician reviewers judged whether each SAE type was an adverse event of special interest (AESI). Risk ratios and risk differences between vaccine and placebo groups were calculated for the incidence of AESIs and SAEs.

    Subject
    COVID-19/prevention & control
    Vaccines
    Geographic Coverage
    United States
    Timeframe
    2020
    Access Rights
    Unrestricted access

  • mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant
    UMB Dataset

    Authors
    Etsuro Nanishi
    Marisa E. McGrath
    Timothy R. O’Meara
    Soumik Barman
    17 more author(s)...
    Description

    This study investigates multiple vaccine strategies to enhance immunogenicity and protection against SARS-CoV-2 in aged mice. The study aims to determine the effect of a booster dose, with an emphasis on older age. Female three and eleven-month-old BALB/c mice were studied over the course of 38 weeks. Mice received BNT162b2 SARS-CoV-2 spike mRNA vaccine series, primary vaccination series, and mock Phosphate-buffered saline (PBS) injections. Single mouse experiments aimed to include 20 mice per group. Sample size and age criteria were chosen empirically based on the results of previous studies. Mice were randomly assigned to different treatment groups.

    Subject
    COVID-19/prevention & control
    Viral Vaccines/genetics
    Access Rights
    Unrestricted access
    Local Experts
    Matthew B. Frieman

  • Evaluation of COVID-19 vaccination strategies with a delayed second dose
    UMB Dataset

    Authors
    Seyed M. Moghadas
    Thomas N. Vilches
    Kevin Zhang
    Shokoofeh Nourbakhsh
    3 more author(s)...
    Description

    Due to constraints in vaccine supply, this agent-based model of COVID-19 transmission was developed to compare the impact of two vaccination strategies: 1) vaccinate more individuals with the first dose of available vaccines and delay the second dose or 2) to continue with the recommended 2-dose series as tested in clinical trials. Model population was stratified into 6 age groups of 0 to 4, 5 to 19, 20 to 49, 50 to 64, 65 to 79, and 80+ years based on United States census data.

    Subject
    COVID-19 Vaccines/administration & dosage
    COVID-19/prevention & control
    SARS-CoV-2/immunology
    Geographic Coverage
    United States
    Access Rights
    Unrestricted access
    Local Experts
    Meagan C. Fitzpatrick

Filter by

Subject Domain
Geographic Coverage
Access Restrictions
Timeframe