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Results Found: 2

  • Prion Replication Environment Defines the Fate of Prion Strain Adaptation
    UMB Dataset

    Authors
    Ilia V. Baskakov
    Elizaveta Katorcha
    Nuria Gonzalez-Montalban
    Natallia Makarava
    1 more author(s)...
    Description

    The research associated with this dataset explored cross-species prion transmission and the impact of cofactor environment on strain adaptation. Utilizing Protein Misfolding Cyclic Amplification with beads (PMCAb), hamster strain 263K was propagated under normal or RNA-depleted conditions first in mouse and then hamster substrates. A variety of readaptation experiments were conducted including brain analysis of hamsters inoculated with different PMCAb-derived material. Dataset includes Western blot and comparative histopathological brain images.

    Subject
    Prion Diseases
    Zoonoses
    Access Rights
    Unrestricted access

  • Sex Differences in the Expression of Calcitonin Gene-Related Peptide Receptor Components in the Spinal Trigeminal Nucleus
    UMB Dataset

    Authors
    Radi Masri
    Yadong Ji
    Alexandra Rizk
    Pamela Voulalas
    4 more author(s)...
    Description

    The prevalence of migraines in females is 3 times greater than in males. Current research has implicated the calcitonin gene-related peptide (CGRP) as a significant factor in the pathophysiology of migraines. This study investigated the sex differences associated with the expression of three protein components of the calcitonin gene-related peptide receptor: calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and receptor component protein (RCP). The research included comparing baseline protein levels in the spinal trigeminal nucleus caudalis (SpVc) and upper cervical spinal cord between male and female rats and whether or not knock-down of the expression of RCP in the SpVc mitigates pain induced by chemical noxious stimulation of the meninges. The dataset includes western blot images (embedded within the associated article), protein expression analysis, and data associated with pain assessment and tests of facial mechanical hypersensitivity and allodynia in males versus females.

    Subject
    Migraine Disorders/physiopathology
    Receptors, Calcitonin Gene-Related Peptide/physiology
    Sex Factors

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