UMB Data Catalog

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  • UMB Dataset

    Prion Replication Environment Defines the Fate of Prion Strain Adaptation

    Authors
    Ilia V. Baskakov
    Elizaveta Katorcha
    Nuria Gonzalez-Montalban
    Natallia Makarava
    1 more author(s)...
    Description

    The research associated with this dataset explored cross-species prion transmission and the impact of cofactor environment on strain adaptation. Utilizing Protein Misfolding Cyclic Amplification with beads (PMCAb), hamster strain 263K was propagated under normal or RNA-depleted conditions first in mouse and then hamster substrates. A variety of readaptation experiments were conducted including brain...

    Subject
    Prion Diseases
    Zoonoses
    Access Rights
    Unrestricted access
  • UMB Dataset

    Sex Differences in the Expression of Calcitonin Gene-Related Peptide Receptor Components in the Spinal Trigeminal Nucleus

    Authors
    Radi Masri
    Yadong Ji
    Alexandra Rizk
    Pamela Voulalas
    4 more author(s)...
    Description

    The prevalence of migraines in females is 3 times greater than in males. Current research has implicated the calcitonin gene-related peptide (CGRP) as a significant factor in the pathophysiology of migraines. This study investigated the sex differences associated with the expression of three protein components of the calcitonin gene-related peptide receptor: calcitonin receptor-like receptor (CLR),...

    Subject
    Migraine Disorders/physiopathology
    Receptors, Calcitonin Gene-Related Peptide/physiology
    Sex Factors