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UMB Dataset
Protection from Cholera with CVD 103-HgR
- Alternate Title(s)
- Efficacy of Single-Dose Live Oral Cholera Vaccine CVD 103-HgR
- Authors
- Wilbur H. ChenMyron M. Levine
- Description
This dataset is the result of a phase 3, randomized, double-blind, placebo-controlled efficacy trial of a single dose live oral cholera vaccine. PXVX0200 was developed to rapidly confer protection to humanitarian relief workers and other travelers visiting cholera-endemic areas as well as residents in regions experiencing outbreaks. Existing licensed vaccines require 2 or 3 (children) doses weeks apart....
- Subject
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Vaccines
- Access Rights
- Approval requiredRegistration required
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UMB Dataset
Safety, Reactogenicity, and immunogenicity of Inactivated Monovalent Influenza A(H5N1) Virus Vaccine Administered With or Without AS03 Adjuvant
- Authors
- Wilbur H. Chen
- Description
This multicenter randomized, controlled, double-blind Phase 1 trial investigated the safety, tolerability, immunogenicity, and feasibility of adding an adjuvant to an influenza vaccine at point-of-use (commonly referred to as the Mix-N-Match study). Inactivated influenza A/Indonesia/05/2005 virus vaccine and the adjuvant, AS03, were provided by the US Department of Health and Human Services (HHS) Biomedical...
- Subject
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Vaccines
- Timeframe
- 2011
- Access Rights
- Registration required
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UMB Dataset
Persistance of Antibody to Influenza A/H5N1 Vaccine Virus: Impact of AS03 Adjuvant
- Authors
- Wilbur H. Chen
- Description
The research associated with this dataset is an extension of a multicenter randomized, controlled, double-blind phase 1 trial that investigated combining an adjuvant (AS03) with an influenza (A/H5N1) vaccine at point-of-use (see “Related Datasets” below). In the original study adult volunteers were given 2 intramuscular doses of vaccine containing 3.75, 7.5, or 15 mcg of hemagglutinin (HA) with or...
- Subject
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Vaccines
- Access Rights
- Registration required