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Persistance of Antibody to Influenza A/H5N1 Vaccine Virus: Impact of AS03 Adjuvant
UMB Dataset

UID: 34

Author(s): Wilbur H. Chen* * Corresponding Author

Description: The research associated with this dataset is an extension of a multicenter randomized, controlled, double-blind phase 1 trial that investigated combining an adjuvant (AS03) with an influenza (A/H5N1) vaccine at point-of-use (see “Related Datasets” below). In the original study adult volunteers were given 2 intramuscular doses of vaccine containing 3.75, 7.5, or 15 mcg of hemagglutinin (HA) with or without adjuvant spaced 21 days apart. Serum samples were taken at 4 intervals ending with day 42 after vaccination. This research assessed the kinetics of antibody responses by analyzing samples taken at day 201 (6 months) and 386 (12 months) postvaccination. Hemagglutination inhibition (HAI) and microneutrilization (MN) responses were evaluated for the homologous virus (A/Indonesia/05/2005) as well as the heterologous virus strains A/Vietnam/1203/2004, A/Anhui/01/2005, A/turkey/Turkey/01/2005, and A/Hubei/1/2010. This dataset includes HAI and MN antibody assessment values for the 3 different doses with and without adjuvant for the homologous virus as well as the 4 drift virus strains.
Timeframe: 2011 - 2012
Geographic Coverage: Baltimore (Md.)

Houston (Tex.)

Nashville (Tenn.)

Seattle (Wash.)

Subject of Study

Subject Domain

Population Age

Adult (19 years to 64 years)

Subject Gender

Female

Male

Keywords

Adjuvants, Immunologic

Avian Influenza

Influenza Vaccines

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