-
UMB Dataset
Prion Replication Environment Defines the Fate of Prion Strain Adaptation
- Authors
- Ilia V. BaskakovElizaveta KatorchaNuria Gonzalez-MontalbanNatallia Makarava1 more author(s)...
- Description
The research associated with this dataset explored cross-species prion transmission and the impact of cofactor environment on strain adaptation. Utilizing Protein Misfolding Cyclic Amplification with beads (PMCAb), hamster strain 263K was propagated under normal or RNA-depleted conditions first in mouse and then hamster substrates. A variety of readaptation experiments were conducted including brain...
- Subject
-
Prion DiseasesZoonoses
- Access Rights
- Unrestricted access
-
UMB Dataset
Region-Specific Response of Astrocytes to Prion Infection
- Authors
- Natallia MakaravaJennifer Chen-Yu ChangRajesh KushwahaIlia V. Baskakov
- Description
Chronic neuroinflammation is a common pathological hallmark of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, ALS, and prion disorders. Both reactive microgliosis and astrogliosis have been identified as having a role in the neuroinflammatory process. Studies of prion diseases of animals and humans have demonstrated activation and proliferation of microglia at the very early subclinical...
- Subject
-
Neurodegenerative DiseasesPrion Diseases
- Access Rights
- Unrestricted access
