UMB Data Catalog

A project of the Health Sciences and Human Services Library
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Results Found: 3
  • UMB Dataset

    Region-Specific Response of Astrocytes to Prion Infection

    Authors
    Natallia Makarava
    Jennifer Chen-Yu Chang
    Rajesh Kushwaha
    Ilia V. Baskakov
    Description

    Chronic neuroinflammation is a common pathological hallmark of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, ALS, and prion disorders. Both reactive microgliosis and astrogliosis have been identified as having a role in the neuroinflammatory process. Studies of prion diseases of animals and humans have demonstrated activation and proliferation of microglia at the very early subclinical...

    Subject
    Neurodegenerative Diseases
    Prion Diseases
    Access Rights
    Unrestricted access
  • UMB Dataset

    Cocaine-induced neuron subtype mitochondrial dynamics through Egr3 transcriptional regulation

    Authors
    Shannon L. Cole
    Ramesh Chandra
    Maya Harris
    Ishan Patel
    8 more author(s)...
    Description

    This dataset was generated to investigate long-lasting neurobiological adaptations to drugs of abuse. This dataset specifically supported the study of cocaine exposure impact of mitochondrial dynamics and morphology through early growth response factor 3 (Egr3) transcriptional regulation of mitochondria-related nuclear gene transcripts. Mitochondria-related nuclear genes were assayed following contingent...

    Subject
    Cocaine/pharmacology
    Early Growth Response Protein 3
    Mitochondrial Dynamics
    Neurons
    Transcription, Genetic/drug effects
    Access Rights
    Unrestricted access
    Approval required
  • UMB Dataset

    Mutations in Diphosphoinositol-Pentakisphosphate Kinase PPIP5K2 are associated with hearing loss in human and mouse

    Authors
    Saima Riazuddin
    Rizwan Yousaf
    Chunfang Gu
    Zubair M. Ahmed
    4 more author(s)...
    Description

    Genetically complex non-syndromic recessively inherited hearing loss (NSRHL) comprises approximately 75% of hereditary deafness. This study investigated NSRHL in two large consanguineous Pakistani families. Exome sequencing coupled with homozygosity mapping was used to identify a missense variant in PPIP5K2 gene associated with nonsyndromic, prelingual sensorineural deafness. Biochemical analysis was...

    Subject
    Hearing Loss
    Point Mutation
    Access Rights
    Unrestricted access